精神病超高危人群社会功能的影响因素研究

doi:10.3969/j.issn.1006-7795.2018.02.008

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (2): 195-198.doi: 10.3969/j.issn.1006-7795.2018.02.008

• 精神分裂症基础和临床 • 上一篇下一篇

精神病超高危人群社会功能的影响因素研究

朱虹, 贾竑晓

首都医科大学附属北京安定医院中西医结合研究室国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室, 北京 100088

收稿日期:2018-01-26 出版日期:2018-03-21 发布日期:2018-04-14
通讯作者: 贾竑晓 E-mail:jhxlj@vip.163.com
基金资助:
北京市自然科学基金（7152069），北京市科委首都临床特色应用研专项（Z151100004015061），北京中医药科技发展基金（QN2016-09），首都卫生发展科研专项（首发2018-1-2122）。

Factors influencing social function in patients at ultra-high risk of psychosis

Zhu Hong, Jia Hongxiao

Laboratory of Integrated Chinese and Western Medicine, Beijing Anding Hospital, Capital Medical University, The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing 100088, China

Received:2018-01-26 Online:2018-03-21 Published:2018-04-14
Supported by:
This study was supported by Natural Science Foundation of Beijing(7152069), Project of Capital Clinical Characteristic Application of Beijing Science and Technology Commission(Z151100004015061), Beijing Science and Technology Development Fund Project of Traditional Chinese Medicine (QN2016-09), Capital Health Development Research Project (SF2018-1-2122).

摘要/Abstract

摘要： 目的研究精神病超高危人群临床特征、认知功能、未治时间和社会功能的关系。方法对49名精神病超高危人群被试进行了临床信息、认知功能、未治时间和社会功能的数据采集和评估，并对相关信息进行了分析。结果患者的社会功能与年龄、发病年龄、受教育年限和未治时间（duration of untreated psychosis，DUP）相关性差异无统计学意义（P>0.05）；与临床症状精神病高危症状量表（Scale of Psychosis-risk Symptoms，SOPS）总分和阴性症状分呈负相关（r=-0.357，P<0.05；r=-0.348，P<0.05）；与认知功能中的连线测验表现呈负相关（r=-0.32，P<0.05）；与简易视觉记忆测验、Stroop测验和持续操作测验表现呈正相关（r=0.324，P<0.05；r=0.295，P<0.05；r=0.407，P=0.000）。使用逐步回归得到最优线性模型（R²=0.231，F=13.491，P=0.001），其中持续操作测验与社会功能呈线性关系（非标准回归系数B=6.046，95%CI：-0.681~0.494，P=0.001），其余因素与社会功能的线性关系不显著（P>0.05）。结论患者的临床症状、认知功能与社会功能关系密切，对制定精神病超高危人群的干预策略有一定的参考作用。

关键词: 精神病超高危, 社会功能, 影响因素

Abstract: Objective To study the relationship between the clinical features, cognitive function, duration of untreated psychosis (DUP), and social function of patients at ultra-high risk of psychosis. Methods The data about clinical information, cognitive function, DUP, and social function of 49 patients were collected and analyzed. Results There was no significant correlation between social function and age, age of onset, education years and DUP (P>0.05). The social function showed a significant negative correlation with total scores of Scale of Psychosis-risk Symptoms (SOPS) and negative symptoms scores (r=-0.357, P<0.05; r=-0.348, P<0.05); It also showed a significant negative correlation with trail making test A (r=-0.32, P<0.05), a positive correlation with the simple visual memory test, the Stroop test and the continuous performance test (CPT) (r=0.324, P<0.05; r=0.295, P<0.05; r=0.407, P=0.000). An optimal linear model was developed by using the stepwise regression (R²=0.231, F=13.491, P=0.001). The relationship between social function and CPT was linear (unstandardized coefficients B=6.046, 95%CI:-0.681-0.494, P=0.001), whereas other factors did not show significant linear relationship with social function (P>0.05). Conclusion The patients' clinical symptoms and cognitive function are closely related with social function, which could be as reference for intervention strategies for ultra-high risk group.

Key words: ultra-high risk for psychosis, social function, affect factors

中图分类号:

R749

朱虹, 贾竑晓. 精神病超高危人群社会功能的影响因素研究[J]. 首都医科大学学报, 2018, 39(2): 195-198.

Zhu Hong, Jia Hongxiao. Factors influencing social function in patients at ultra-high risk of psychosis[J]. Journal of Capital Medical University, 2018, 39(2): 195-198.

参考文献

[1] Yung A R, Phillips L J, Yuen H P, et al. Psychosis prediction:12-month follow up of a high-risk ("prodromal") group[J]. Schizophr Res,2003, 60(1):21-32.
[2] Fusar-Poli P, Rocchetti M, Sardella A, et al. Disorder, not just state of risk:meta-analysis of functioning and quality of life in people at high risk of psychosis[J]. Br J Psychiatry, 2015, 207(3):198-206.
[3] Lee S J, Kim K R, Lee S Y, et al. Impaired social and role function in ultra-high risk for psychosis and first-episode schizophrenia:its relations with negative symptoms[J]. Psychiatry Investig, 2017, 14(5):539-545.
[4] 麦克拉申. 精神病风险综合征-诊断和随访手册[M]. 北京:人民卫生出版社,2012.
[5] 于欣. MCCB中国常模手册[M]. 北京:北京大学医学出版社, 2014.
[6] Carrión R E, McLaughlin D, Goldberg T E, et al. Prediction of functional outcome in individuals at clinical high risk for psychosis[J]. JAMA Psychiatr,2013,70(11):1133-1142.
[7] Meyer E C, Carrión R E, Cornblatt B A, et al. The relationship of neurocognition and negative symptoms to social and role functioning over time in individuals at clinical high risk in the first phase of the North American Prodrome Longitudinal Study[J]. Schizophr Bull,2014, 40(6):1452-1461.
[8] Glenthøj L B, Hjorthøj C, Kristensen T D, et al. The effect of cognitive remediation in individuals at ultra-high risk for psychosis:a systematic review[J]. NPJ Schizophr, 2017, 3:20.
[9] Mechelli A, Lin A, Wood S, et al. Using clinical information to make individualized prognostic predictions in people at ultra high risk for psychosis[J]. Schizophr Res,2017, 184:32-38.
[10] Seidman L J, Shapiro D I, Stone W S, et al. Association of neurocognition with transition to psychosis:baseline functioning in the second phase of the north American prodrome longitudinal study[J]. JAMA Psychiatr,2016, 73(12):1239-1248.
[11] Schlosser D A, Campellone T R, Biagianti B, et al. Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis[J]. Schizophr Res, 2015, 169(1-3):204-208.
[12] Marshall M, Lewis S, Lockwood A, et al. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients:a systematic review[J]. Arch Gen Psychiatr, 2005, 62(9):975-983.
[13] Heeramun-Aubeeluck A, Liu N, Fischer F, et al. Effect of time and duration of untreated psychosis on cognitive and social functioning in Chinese patients with first-episode schizophrenia:A 1-year study[J]. Nord J Psychiatr,2015, 69(4):254-261.
[14] 刘辉,刘珊珊,贾竑晓.首发精神分裂症未治疗时间的变化及相关因素[J].首都医科大学学报,2016,37(2):168-171.
[15] 孙妍,郭建兵,李贺斌,等.社会支持对精神分裂症患者生活质量和康复效果的影响[J].解放军医药杂志,2017,29(5):72-74,78.

精神病超高危人群社会功能的影响因素研究

Factors influencing social function in patients at ultra-high risk of psychosis

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	齐涵, 贾鹏举, 王春燕, 胡维明, 付晨光, 夏晨妮, 姜涛, 吴曼琴, 王学好, 张长春, 闫芳. 心理健康教育对北京市养老机构老年人的干预效果及其影响因素[J]. 首都医科大学学报, 2023, 44(1): 27-34.
[2]	王映权, 冯琳, 左颖婷, 童朝晖, 梁立荣. 慢性阻塞性肺疾病急性加重临床路径的实施及影响因素[J]. 首都医科大学学报, 2023, 44(1): 35-41.
[3]	鞠蕊, 阮祥燕, 代荫梅, 白勇涛, 杨瑜, 许新, 程姣姣, 杨幸子, 施琰红, 孙艳华, 李瑞玲. 女性性功能障碍的影响因素研究[J]. 首都医科大学学报, 2022, 43(3): 357-363.
[4]	姚懿, 唐晓芳, 宋莹, 姜琳, 乔树宾, 袁晋青. 急性冠状动脉综合征患者抗血小板药物抵抗的影响因素分析[J]. 首都医科大学学报, 2021, 42(5): 799-803.
[5]	苗芳芳, 冯雪辛, 侯瑞雪, 段庆芳, 王天龙. 神经外科手术患者术后排气时间影响因素分析[J]. 首都医科大学学报, 2021, 42(5): 816-821.
[6]	仪玉伟, 闫芳, 靳玉宏, 肖存利. 精神分裂症住院患者危险行为的影响因素分析[J]. 首都医科大学学报, 2021, 42(2): 323-327.
[7]	宋楠, 贾竑晓. 人格解体患者认知功能及与临床症状和社会功能的相关性[J]. 首都医科大学学报, 2020, 41(1): 59-63.
[8]	王蕊, 宋楠, 朱虹, 贾竑晓. 人格解体障碍患者社会功能、生活质量及满意度的状况及其相关性分析[J]. 首都医科大学学报, 2019, 40(2): 214-219.
[9]	孙琦, 王皓, 刘洪琪, 王友信. 2017年潍坊市某高校新生亚健康状态及影响因素分析[J]. 首都医科大学学报, 2019, 40(2): 276-281.
[10]	杜娟, 阮祥燕, Alfred O. Mueck. 口服避孕药对多囊卵巢综合征患者性功能的影响[J]. 首都医科大学学报, 2018, 39(4): 499-504.
[11]	李秀娜, 周玉杰. 北京通州台湖地区65岁以上高血压老人心理健康现况及影响因素研究[J]. 首都医科大学学报, 2018, 39(1): 112-119.
[12]	潘守强, 张毅. 肺上叶前段占位性病变性质判定相关因素分析[J]. 首都医科大学学报, 2016, 37(6): 767-772.
[13]	刘思维, 贾伟华, 周立春. 急性脑梗死后非溶栓患者出血转化的影响因素分析[J]. 首都医科大学学报, 2016, 37(4): 534-537.
[14]	刘晨. 丙型肝炎患者抗病毒治疗依从性影响因素和护理对策[J]. 首都医科大学学报, 2015, 36(3): 501-504.
[15]	龚敬, 段金萍, 刘博, 杨毅, 周芸, 庄晓明, 刘刚, 金昕. 糖尿病患者听力损失的临床特点分析[J]. 首都医科大学学报, 2015, 36(1): 84-89.