首都医科大学学报 ›› 1989, Vol. 10 ›› Issue (1): 6-8.

• 论著 • 上一篇    下一篇

实验性IgA肾病

郑国芬, 董小黎, 吴位育   

  1. 首都医学院病理解剖学教研室
  • 收稿日期:1988-09-21 修回日期:1900-01-01 出版日期:1989-01-15 发布日期:1989-01-15

Experimental IgA Nephropathy

Zheng Guofen   

  1. Department of Patho-anatomy, Capital Institute of Medicine
  • Received:1988-09-21 Revised:1900-01-01 Online:1989-01-15 Published:1989-01-15

摘要: 大鼠皮下注射四氯化碳以制造肝硬变模型后,用PAP免疫组织化学染色法显示出在肾小球毛细血管的基底膜上有IgA的沉积,即继发性IgA肾病的形成,实验动物用药1个月后形成肝硬变,用药33~196d的大鼠肾小球内有明显的IgA沉着。IgA不见于肝硬变形成前和用药后238d的大鼠。

关键词: 肾小球, 肝硬变, IgA沉积物

Abstract: Renal glomerular lesions in experimental hepatic cirrhosis induced by carbon tetrachloride were studied, Hepatic cirrhosis was formed one month after administration of carbon tetrachloride, Glomerular capillary wall deposits of IgA (secondary IgA nephropathy) was demonstrated by PAP immuno-histochemical method. Large amounts of IgA deposits were clearly seen in 33~196 day rats. IgA deposits were not seen before the formation of hepatic cirrhosis and 238 day old rats.

Key words: glomcrulus, cirrhosis, IgA dcposit