凝集素受体在正常食管上皮及食管鳞状细胞癌中分布的研究

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (2): 115-118.

凝集素受体在正常食管上皮及食管鳞状细胞癌中分布的研究

沈丹华, 朱昌仁

首都医学院附属北京天坛医院病理科

收稿日期:1993-01-18 修回日期:1900-01-01 出版日期:1994-04-15 发布日期:1994-04-15

Distribution of Lectin PNA, PSA, DBA Receptors in the Normal Esophageal Epithelium and Esophageal Cancer

Shen Danhua, Zhu Changren

Department of Pathology, Beijing Tiantan Hospital, Capital Institule of Medicine

Received:1993-01-18 Revised:1900-01-01 Online:1994-04-15 Published:1994-04-15

摘要/Abstract

摘要：

应用花生授集素(PNA),碗豆凝集素(PSA)和双花扁豆凝集紊(DBA)对4例非肿瘤死亡的尸体解剖食管上皮和30例食管鳞状细胞瘤及其周围的食管粘膜进行免疫标记,以分析在发生癌变时食管粘膜上皮细胞表面的糖墓变化.结果表明:4例尸解食管上皮对PNA,PSA标记呈阴性,而对DBA标记呈阳性.在食管粘膜上皮发生府变时PNA及PSA标记转为阳性,阳性表达率与肿瘤分化程度有关.相反,在食管上皮癌变时DBA标记的阳性率下降甚至全部消失.说明细胞在发生癌变时会导致细胞表面的糖链结构发生变化.另外,食管痛周围形态学正常的粘膜上皮对PNA及PSA标记也有16%和12%的阳性表达,推测可能在粘膜上皮细胞尚未发生形态学改变时其细胞表面的糖荃链就已经发生了变化.

关键词: 凝集素, 食管上皮, 食管癌

Abstract:

30 cases of esophageal cancerous tissues and 4 cases of esophageal epithelium from autopsy of other diseases were marked immunohistochemically with lectin PNA,PSA and DBA. The results showed that negative staining reaction of PNA and PSA appeared in the 4 cases of autopsy esophageal epithelium and positive DBA staining reaction appeared in these cases.Where as in malignant changes,the PNA and PSA reaction turn to positive and DBA staines declined or even disappeared. It is explained that the changes of cellular glycoconjugate can occur in malignant state.In addition, positive saining reaction of PNA and PSA appeared in the 7 cases of normal esophageal epithelium which near the cancer.It is conjectured that the changes of glycoconjugate of esophageal epithelium cells are occured before the apperance morthlogyical changes.The relationshipbetween the location of lectin receptors and the degree of differentiation or infilitrativing growth of tumors was discussed.

Key words: lectin, esophageal epithelium, esophageal cancer

中图分类号:

R730.21

沈丹华;朱昌仁. 凝集素受体在正常食管上皮及食管鳞状细胞癌中分布的研究[J]. 首都医科大学学报, 1994, 15(2): 115-118.

Shen Danhua;Zhu Changren. Distribution of Lectin PNA, PSA, DBA Receptors in the Normal Esophageal Epithelium and Esophageal Cancer[J]. Journal of Capital Medical University, 1994, 15(2): 115-118.

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