关键词: 阻塞性睡眠呼吸暂停低通气综合征, 植物凝集素样氧化低密度脂蛋白受体-1, 氧化低密度脂蛋白, 丙二醛, 氧化应激

Abstract:

Objective To investigate the changes of serum lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and the influence from oxidative stress in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods Totally 94 candidates were divided into three groups according to the apnea-hypopnea index(AHI), including normal control group(n=30), mild to moderate group(n=29), severe group(n=35). After the monitoring by polysomnography(PSG), the blood samples were obtained to measure the levels of serum LOX-1, oxidized low-density lipoprotein(ox-LDL) and malondialdehyde(MDA). Results The levels of serum LOX-1, ox-LDL, MDA in severe OSAHS group were significantly higher than that in the mild to moderate group and control group(P<0.01). The level of serum LOX-1 in OSAHS patients was positively correlated with serum ox-LDL and MDA(r=0.693, 0.460, respectively, all P<0.01). The level of ox-LDL and SaO₂min were the high risk factors to influence the level of serum LOX-1 in patients with OSAHS(r=0.705, 0.734, respectively, all P<0.01). Conclusion The intermittent hypoxia caused by OSAHS can regulate the levels of LOX-1 through oxidative stress, and can further promote the formation and development of atherosclerotic in patients with OSAHS.

Key words: obstructive sleep apnea-hypopnea syndrome, lectin-like oxidized low-density lipoprotein receptor-1, oxidized low-density lipoprotein, malondialdehyde, oxidative stress