腺苷超声心动图负荷试验诊断冠心病的应用价值

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (2): 136-139.

腺苷超声心动图负荷试验诊断冠心病的应用价值

陈欣, 杨明, 邹凤军, 丁五麟, 张小航, 王青, 高亢, 潘国忠, 尹朝霞, 韩凌, 胡文泽, 岑强

1. 首都医科大学宣武医院心血管内科;2. 首都医科大学心脏病学系

收稿日期:2005-03-04 修回日期:1900-01-01 出版日期:2005-04-24 发布日期:2005-04-24
通讯作者: 陈欣

Clinical Value of Adenosine Stress Echocardiography in Diagnosis of Coronary Artery Disease

Chen Xin, Yang Ming, Zou Fengjun, Ding Wuling, Zhang Xiaohang, Wang Qing, Gao Kang, Pang Guozhong, Yin Zhaoxia, Han Ling, Hu Wenze, Cen Qiang

1. Department of Cardiology, Fuxing Hosipital, Capital University of Medical Sciences;2. Department of Cardiology, Capital University of Medical Sciences

Received:2005-03-04 Revised:1900-01-01 Online:2005-04-24 Published:2005-04-24

摘要/Abstract

摘要：

目的评价腺苷超声心动图负荷试验(ASE)诊断冠心病的敏感性、特异性与安全性。方法临床拟诊冠心病(CAD)患者100例,分别静脉注射腺苷140μg/(kg·min),用药时间6min,总剂量0.84mg/kg,并同时记录室壁运动、患者症状和不良反应等。左室16节段中出现室壁运动异常为阳性。64例患者于试验后1周内行冠状动脉造影,并以其为金标准,计算ASE的敏感性和特异性等。结果 ASE诊断CAD的敏感性为68.8%,特异性为81.2%,准确性为75%。诊断CAD单支、双支和三支病变的敏感性分别为60.6%、70.0%和83.3%。ASE不良反应发生率为59.0%,但症状轻微,无严重不良反应。结论 ASE是一种较理想的诊断CAD的无创检查方法。

关键词: 腺苷, 超声心动图负荷试验, 室壁运动异常, 冠心病

Abstract:

Objective The aim of the study was to assess the clinical value of adenosine stress echocardiography in diagnosis of CAD. Methods Adenosine stress echocardiography(ASE) was performed in 100suspectable CAD patients with infusion of adenosine 140 μg/(kg·min) in 6min. Left ventricular wall motion was recorded during the procedure. Positive criterion was defined as the appearance of wall motion abnormality(WMA). And then among them 64 patients underwent the coronary angiography a week after ASE. Coronary angiography was taken as the golden standard for CAD and comparion of ASE. Results The total sensitivity of this ASE was 68.8% and the total specificity was 81.2% in diagnosis of CAD. Furthermore the sensitivity for detection of myocardial ischemia in one, two and three-vessel CAD sub-groups were 60.6%, 70.0% and 83.3% respectively. Side effects due to adenosine in fusion were always minimal and well tolerated by the patients. Conclusion Adenosine stress echocardiography can be safely performed in suspectable CAD patients with high sensitivity and specificity.

Key words: adenosine, stress echocardiography, wall motion abnormality, coronary heart disease

中图分类号:

R541.4

陈欣;杨明;邹凤军;丁五麟;张小航;王青;高亢;潘国忠;尹朝霞;韩凌;胡文泽;岑强. 腺苷超声心动图负荷试验诊断冠心病的应用价值[J]. 首都医科大学学报, 2005, 26(2): 136-139.

Chen Xin;Yang Ming;Zou Fengjun;Ding Wuling;Zhang Xiaohang;Wang Qing;Gao Kang;Pang Guozhong;Yin Zhaoxia;Han Ling;Hu Wenze;Cen Qiang . Clinical Value of Adenosine Stress Echocardiography in Diagnosis of Coronary Artery Disease[J]. Journal of Capital Medical University, 2005, 26(2): 136-139.

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