关键词: 冠状动脉粥样硬化性心脏病, 高胆固醇血症, 辛伐他汀, 治疗学

Abstract: Objective This study was to evaluate the regulating effect of simvastatin(Zocor) on lipids and lipid ratios of the elderly patients with coronary heart disease(CHD).Methods We selected 106 elderly patients with CHD associated with primary hyperlipemia and gave them simvastatin,20 mg/d.The patients were treated and had been followed up for 12 months.If the serum total cholesterol(TC) of the patients were ≤3.6 mmol/L(140 mg/dL) and low-density lipoprotein cholesterol(LDL-C) ≤1.8 mmol/L(70 mg/dL),the dosage of simvastatin was changed to 10 mg/d in follow up.Results After 12 months,the TC、LDL-C、triglycerides and apolipoprotienB(ApoB) of the 104 patients reduced by 38%,45%,20% and 25% respectively(P<0.001),while high-density lipoprotein cholesterol(HDL-C) and apolipoprotienA1(ApoA1) arose by 7% and 10%(P<0.05) respectively.The radios of TC to HDL-C,LDL-C to HDLC and ApoB to ApoA1 reduced to 3.30,1.71 and 0.62 respectively((P<)0.001).In the 6^th and 12^th month 87.3% and 95.2% of the patients took simvastatin 10 mg/d respectively in case their(TC≤)3.6 mmol/L(140 mg/dL) and LDL-C ≤1.8 mmol/L(70 mg/dL).There was no abnormal increasing in serum aminotransferase and creatine kinase.Conclusion The regulating effects of simvastatin on lipids and lipid ratios of the elderly patients with CHD are definite and safe.

Key words: coronary heart disease, hypercholesterolemia, simvastatin, therapeutics