首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (5): 663-665.

• 临床研究 • 上一篇    下一篇

慢性心力衰竭和睡眠呼吸暂停的相关性研究

田海皊, 李莉, 倪如旸, 许毓申   

  1. 首都医科大学附属北京同仁医院心脏中心
  • 收稿日期:2006-02-04 修回日期:1900-01-01 出版日期:2006-10-24 发布日期:2006-10-24

Research of Correlation between Sleep Apnea and Chronic Heart Failure

Tian Hailing, Li Li, Ni Ruyang, Xu Yushen   

  1. Department of Cardiology, Beijing Tongren Hospital, Capital University of Medical Sciences
  • Received:2006-02-04 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24

摘要: 目的 监测住院心力衰竭(以下简称心衰)病人睡眠呼吸暂停(sleep apnea,SA)的发生率及对心功能的影响.方法 选择在北京同仁医院心脏中心住院的68例慢性心衰患者,NYHA Ⅱ~Ⅳ级,左心室射血分数(left ventricular ejection fraction,LVEF)≤50%,经多导睡眠监测(polysomnography, PSG)分为心衰伴SA组:呼吸暂停低通气指数(apnea-hypopnea-index,AHI)≥5次/h;心衰不伴SA组:(AHI《5次/h).结果 68例心衰病人中有42例合并SA,以中枢性SA为主.心衰伴SA组患者的二氧化碳分压(PaCO2)、最低血氧饱和度(LSaO2)、LVEF较不伴SA组降低,左心室舒张末期内径(LEVDD)较不伴SA组增大,差异均有统计学意义(分别为P=0.00, P=0.000, P=0.007, P=0.000).Logistic回归分析显示,心衰伴SA的影响因素有PaCO2、LSaO2、LVEF(P=0.006, P=0.003, P=0.040).结论 心衰病人易出现中枢性睡眠呼吸暂停;睡眠呼吸暂停可影响血氧饱和度,加重低氧血症, 并使心功能恶化.

关键词: 睡眠呼吸暂停, 慢性心力衰竭

Abstract: Objective To monitor the prevalence of sleep apnea in the inpatients with chronic heart failure and investigate whether sleep apnea affects heart function.Methods 68 inpatients with symptomatic chronic heart failure(CHF) in NYHA functional classesⅡ to Ⅳ and LVEF less than and/or equal 50%,were divided into two groups with polysomnography: inpatients with CHF and SA(apnea-hypopnea-index,AHI≥5 episodes per hour) and inpatients with CHF without SA(apnea-hypopnea-index,AHI<5 episodes per hour).Results 42 patients had sleep apnea in 68 patients with CHF.Central sleep apnea was in majority.PaCO2、LSaO2 and LVEF were lower in patients with SA compared with those without SA.Left ventricular end-diastolic diameter was longer(P=0.000,P=0.000,P=0.007,P=0.000,respectively).By logistic regression analysis: PaCO2,LSaO2 and LVEF of the SA group were lower(P=0.006,P=0.003,P=0.040).Conclusion Inpatients with CHF usually suffer from central sleep apnea.Sleep apnea decreases oxygen saturation,aggravates hypoxia and brings about the significant adverse effects on heart function of inpatients with CHF.

Key words: sleep apnea, chronic heart failure

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