首都医科大学学报 ›› 2007, Vol. 28 ›› Issue (6): 675-678.

• 诺贝尔奖专栏 • 上一篇    下一篇

瞄准疾病的利器——英美科学家因基因靶向技术获2007年诺贝尔生理学或医学奖

任振华, 关云谦, 张愚   

  1. 首都医科大学宣武医院细胞治疗中心
  • 收稿日期:2007-11-16 修回日期:1900-01-01 出版日期:2007-12-24 发布日期:2007-12-24
  • 通讯作者: 张愚,Correspondingauthor,E-mail:Yaz@bjsap.org

Sharp Weapon Aiming at Diseases——The Nobel Prize in Physiology or Medicine for 2007 Jointly to American and British Scientists for Gene Targeting

Ren Zhenhua, Guan Yunqian, Zhang Yu   

  1. Cell Therapy Center, Xuanwu Hospital, Capital Medical University
  • Received:2007-11-16 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24

摘要: 瑞典卡罗林斯卡医学院2007年10月8日宣布,将2007年诺贝尔生理学或医学奖授予美国人马里奥?卡佩基、奥利弗?史密斯和英国人马丁?埃文斯,以表彰他们在改造活体内特定基因的基因靶向技术等方面做出的奠基性贡献。本文从3位获奖科学家的简介、主要贡献和基因靶向技术的意义等方面进行综述。

关键词: 基因靶向技术, 诺贝尔生理学或医学奖

Abstract: 8th October 2007 The Nobel Assembly at Karolinska Institute has decided to award The Nobel Prize in Physiology or Medicine for 2007 jointly to Mario R.Capecchi,Martin J.Evans and Oliver Smithies for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells".In this paper,we introduce contributions of the three winners,and the significance of the discovery of gene targeting.

Key words: gene targeting, Nobel Prize in Physiology or Medicine