关键词: HIV-1, 宿主蛋白, 相互作用

Abstract: Human immunodeficiency virus type 1(HIV-1) is a causative agent of acquired immunodeficiency syndrome(AIDS) in humans.In the last decade,the functions of HIV-1-encoded genes have been intensively studied.These studies have contributed to the development of the effective anti-AIDS drugs directing against the HIV-1-encoded enzymes,namely reverse transcriptase and protease.However,even the combination of these drugs is not sufficient enough to stop the progression of AIDS partly due to the emergence of drug-resistant HIV-1 mutants as well as the severe side effects.Understanding the molecular mechanisms by which cellular factors support the efficient replication of HIV-1 should contribute to develop means to control the progression of AIDS.Here we review the host factors involved in the replication of HIV-1 and highlight some findings that have a substantial impact on the retroviral research.

Key words: HIV-1, host proteins, interaction