关键词: 骨化性肌炎, 指/趾, 畸形

Abstract: Objective To investigate the clinical characteristic,image manifestation,diagnosis and the therapeutic methods of the myositis ossificans progressiva(MOP).Methods Five pediatric patients with MOPwere reported.The clinical manifestation,changes in imageology,diagnosis,and the motivation of aggravation were analyzed by using retrospective analysis.The literatures relevant to MOPwere reviewed.Results The average age of onset ranges from 7 to 11 years old in all 5 cases(4 boys and 1 girl).MOP in all the patients were represented as recurrence of local tissue swelling,bone calcification accompanied by disturbance in adjacent joint motion,distinctive malformation of digiti,and corresponding changes in imageology.As the MOPaggravated progressively,trauma and local stimulation could exacerbate the pathogenetic progress.Conclusion MOPis a rare autosomal dominant inherited disease and could be early diagnosed by clinical manifestation and the distinctive malformation of digiti.Misdiagnosis is common and will impact the development of the disease.There has been no special treatment at present and the focus of management should base on early diagnosis as well as avoiding the motivation which might aggravate the disease.

Key words: myositis ossificans, digiti, malformation