首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (6): 733-736.doi: 10.3969/j.issn.1006-7795.2009.06.002

• 耳鼻咽喉头颈外科进展 • 上一篇    下一篇

过敏性鼻炎血清特异性IgE与皮肤点刺试验的关联性分析

张媛1, 刘承耀2, 张罗1,2,3   

  1. 1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科;2. 北京市耳鼻咽喉科研究所;3. 耳鼻咽喉头颈科学教育部重点实验室
  • 收稿日期:2009-09-22 修回日期:1900-01-01 出版日期:2009-12-21 发布日期:2009-12-21
  • 通讯作者: 张罗

Correlation Analysis of Serum Specific IgE and Skin Prick Test in Allergic Rhinitis Patients

ZHANG Yuan1, LIU Cheng-yao2, ZHANG Luo1,2,3   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University;2. Beijing Institute of Otorhinolaryngology;3. Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education of China
  • Received:2009-09-22 Revised:1900-01-01 Online:2009-12-21 Published:2009-12-21

PDF

946

被引次数

22

摘要：

目的 评估血清特异性IgE检测与皮肤点刺试验在诊断过敏性鼻炎中的关联性。方法 皮肤点刺试验中尘螨阳性的过敏性鼻炎患者82例,采用瑞典法玛西亚公司UniCAP100系统检测血清尘螨特异性IgE,包括屋尘螨及粉尘螨,统计分析二者的关联性。结果 82例尘螨过敏患者中,55例尘螨血清特异性IgE检测结果大于或等于1级, 特异性IgE水平与皮肤点刺试验结果的等级呈正相关(屋尘螨rs=0.58,粉尘螨rs=0.60)。不同年龄段患者的血清特异性IgE检测结果与皮肤点刺试验的相关系数随年龄的增长而增大,40岁以上患者二者的检测结果无相关性。结论 尘螨过敏性鼻炎患者血清特异性IgE水平与皮肤点刺试验结果呈正相关,且随患者年龄变化而有所差异。诊断40岁以上患者时,推荐同时进行2种检测。

关键词: 过敏性鼻炎, 诊断, 特异性IgE, 皮肤点刺试验

Abstract:

Objective To evaluate the correlation between serum specific IgE and skin prick test for the diagnosis of allergic rhinitis. Methods A total of 82 individuals with house dust mites related allergic rhinitis symptoms and positive SPT results were enrolled. The UniCAP100 system was employed to detect the house dust mites specific IgE which includes dermatophagoides pteronyssinus and dermatophagoides farinae. Results Of the 82 subjects with HDM-related symptoms and positive SPT results, 55 individuals showed equal to or greater than 1 class sIgE level for both Dermatophagoides pteronyssinus and Dermatophagoides farinae. Increasing sIgE level correlated with higher SPT grades in both Der p(rs=0.58) and Der f(rs=0.60). In 41 to 60 years age group, however, the correlation was not statistically significant. Meanwhile, the correlation coefficient exhibited increased value with aging. Conclusion The positive correlation between SPT and sIgE reaction to HDM varied according to age of the patients. For patients over 40 years of age, both of the exams should be recommended for detecting allergy to HDM.

Key words: allergic rhinitis, diagnosis, specific-immunoglobulin E, skin prick test

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