首都医科大学学报 ›› 2010, Vol. 31 ›› Issue (2): 213-216.

• 儿科学专题 • 上一篇    下一篇

重视儿童非肿瘤性EB病毒感染疾病的研究

谢正德, 申昆玲*   

  1. 首都医科大学附属北京儿童医院北京市儿科研究所病毒研究室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-04-21 发布日期:2010-04-21
  • 通讯作者: 申昆玲

Emphasis on the Study of Non-Malignant Diseases Associated with EpsteinBarr Virus Infection in Children

XIE Zheng-de, SHEN Kun-ling*   

  1. Laboratory of Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Captial Medical University
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-04-21 Published:2010-04-21
  • Contact: SHEN Kun-ling

摘要: Epstain-Barr病毒(Epstain-Barr virus,EBV)是一种重要的肿瘤相关病毒,成人感染率超过90%。EB病毒与鼻咽癌、霍奇金和非霍奇金淋巴瘤、胃癌、移植后淋巴增生症等多种肿瘤的发生密切相关。本文介绍了EB病毒感染的实验室诊断方法及其临床应用,重点介绍了儿童常见非肿瘤性EB病毒感染疾病(传染性单核细胞增多症、慢性活动性EB病毒感染、EB病毒相关噬血淋巴组织细胞增生症)的临床特征、诊断指南及需要进一步研究的问题。

关键词: EB病毒, 传染性单核细胞增多症, 慢性活动性EB病毒感染, EB病毒相关噬血淋巴组织细胞增生症, 儿童

Abstract: Epstain-Barr virus(EBV) is an important tumor-related virus, infects over 90% of the world's adult population. EBV is also associated with a wide variety of malignancies including nasopharyngeal carcinoma(NPC), Hodgkin and nonHodgkin lymphomas, gastric carcinoma, posttransplant lymphoproliferative disorder(PTLD). This review introduced laboratory diagnostic assays of EBV infection, and focused on clinical feature and diagnostic guidline of non-malignant diseases associated with EBV infection in children(including infectious mononucleosis, chronic active Epstein-Barr virus infection, EpsteinBarr virus-related hemophagocytic lymphohistiocytosis syndrome). Fields of these diseases needed further research were also introduced.

Key words: EpstainBarr virus, infectious mononucleosis, chronic active EpsteinBarr virus infection, EpsteinBarr virusrelated hemophagocytic lymphohistiocytosis syndrome, children

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