首都医科大学学报 ›› 2011, Vol. 32 ›› Issue (2): 190-193.

• 艾滋病基础与流行病学研究 • 上一篇    下一篇

HIV-1感染者中HCV感染对于隐匿性HBV感染的影响

梁红霞1，余祖江1，张倩1，李志勤1，潘延凤1，李娟1，江河清1，李建生1，何云2*   

  1. 1. 郑州大学第一附属医院感染科； 2. 郑州市第六人民医院感染科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-04-21 发布日期:2011-04-21
  • 通讯作者: 何云

Influences of HCV Infection on Incidence of Occult HBV Infection in Patients Infected with HIV-1

LIANG Hong-xia1, YU Zu-jiang1, ZHANG Qian1, LI Zhi-qin1, PAN Yan-feng1, LI Juan1, JIANG He-qing1, LI Jian-sheng1, HE Yun2*   

  1. 1. Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University;2. Department of Infectious Disease, The Sixth People’s Hospital of Zhengzhou
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-04-21 Published:2011-04-21
  • Contact: HE Yun

PDF

327

被引次数

8

摘要： 目的 探讨在人免疫缺陷病毒-1（human immunodeficiency virus-1，HIV-1）感染者中丙型肝炎病毒（hepatitis C virus，HCV）感染对于隐匿性乙型肝炎病毒（hepatitis B virus，HBV）感染的影响。
方法 研究对象为河南某艾滋病治疗示范区中178例乙型肝炎表面抗原(hepatitis B surface antigen，HBsAg)阴性的经有偿献血感染HIV-1未经抗病毒治疗的患者，检测项目包括肝功能，HBV及HCV血清标志物，HBV DNA和HCV RNA。分析HIV-1阳性，抗HCV阳性、抗HCV阴性组及HIV-1/HCV感染组中不同HCV RNA载量组HBV病原学检测结果方面的差异。
结果 178例HBsAg阴性的HIV-1感染者中，HBV-M全阴性35例；单独抗HBs阳性25例；单独抗HBc阳性51例；HBsAb及HBcAb均阳性 34例。抗HCV阳性HIV-1感染者与抗HCV阴性HIV-1感染者的年龄、性别比较差异无统计学意义（P>0.05）；丙氨酸转移酶（alanine transaminase，ALT）、天冬氨酸氨基转移酶（aspartate aminotransferase ，AST）浓度比较差异有统计学意义（P<0.05）；总胆红素（total bilirubin，TBIL）浓度比较差异无统计学意义（P>0.05）；乙肝标志物（HBV marker，HBV-M）阴性、单独乙肝表面抗体(hepatitis B surface antibody，HBsAb)阳性、单独乙肝核心抗体（hepatitis B core antibody，HBcAb）阳性、HBsAb及HBcAb均阳性及HBV DNA阳性例数比较差异均无统计学意义（P>0.05）。不同HCV RNA载量患者HBV DNA检测结果比较差异无统计学意义（P>0.05）。
结论 经有偿献血感染HIV-1人群中，HCV感染及HCV RNA载量高低与隐匿性HBV感染的发生无关；但合并HCV感染可加重HIV-1感染者的肝功能损害。

关键词: 人免疫缺陷病毒, 丙型肝炎病毒, 隐匿性HBV感染

Abstract: Objective To investigate the influences of HCV infection on occult HBV infection in patients infected with HIV-1.
Methods The study enrolled 178 HBsAg-negative treatment-naive HIV-1 patients who transmitted by commercial blood donation in an HIV/AIDS CARE site in Henan province. Many parameters were detected, including liver function, HBV serologic markers(HBsAg, Anti-HBs, HBeAg, anti-HBe and anti-HBc), HCV antibody, HBV DNA and HCV RNA. Analyses were performed to compare the differences of HBV etiological markers in antiHCV+ group, anti-HCV- group and different HCV RNA groups.
Results Among the 178 HBsAg-negative HIV-infected patients, 35 were HBV-M negative, 25 anti-HBs positive only, 25 anti-HBc positive only, 34 with both anti-HBs and anti-HBc positive. There were no significant differences in ages and gender between anti-HCV+ group and anti-HCV- group(P>0.05). There were significant differences in ALT and AST(P<0.05) but not total bilirubin between anti-HCV+ group and anti-HCV- group. There were no significant differences in HBV-M negative, isolated HBsAb positive only, isolated anti-HBc positive only, anti-HBs and anti-HBc double positive, HBV DNA positive between anti-HCV+ group and anti-HCV- group. There were no significant differences in HBV DNA positive rate between different HCV RNA groups(P>0.05).
Conclusion In the HIV-infected patients who transmitted by commercial blood donation, HCV infection and viral loads of HCV RNA had no correlation with incidence of occult HBV infection, but HCV co-infection could aggravate the liver damage.

Key words: human immunodeficiency virus, hepatitis C virus, occult HBV infection

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