白细胞介素-8-251T/A基因多态性和肺癌易感性的Meta分析

doi:10.3969/j.issn.1006-7795.2014.06.007

首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (6): 711-716.doi: 10.3969/j.issn.1006-7795.2014.06.007

• 胸外科学:从基础到临床 • 上一篇下一篇

白细胞介素-8-251T/A基因多态性和肺癌易感性的Meta分析

真德智¹, 王晓彬², 李云松¹, 李杰³, 韩毅¹, 刘志东¹

1. 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所胸外科, 北京 101149;
2. 内蒙古林业总医院胸心血管外科, 内蒙古牙克石 022150;
3. 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所肿瘤科, 北京 101149

收稿日期:2014-10-16 发布日期:2014-12-15
通讯作者: 刘志东 E-mail:liuzhidong@ccmu.edu.cn
基金资助:
北京市科学技术委员会科技计划资助项目(Z131107002213048)

Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility: a meta-analysis

Zhen Dezhi¹, Wang Xiaobin², Li Yunsong¹, Li Jie³, Han Yi¹, Liu Zhidong¹

1. Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;
2. Department of Thoracic Cardiovascular Surgery, Inner Mongolia Forestry General Hospital, Yakeshi 022150, Inner Mongolia Autonomous Region, China;
3. Department of Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China

Received:2014-10-16 Published:2014-12-15
Supported by:
This study was supported by Scientific Project of Beijing Municipal Science and Technology Commission(Z131107002213048).

摘要/Abstract

摘要：

目的本研究对白细胞介素-8-251 T/A(interleukin-8-251 T/A,IL-8-251 T/A)(rs4073)与肺癌发生风险相关性文献进行Meta分析来评价两者相关性特征。方法检索2013年12月1日之前PubMed中白细胞介素-8-251 T/A(interleukin-8-251 T/A,IL-8-251T/A)(rs4073)基因多态性与肺癌发生风险相关性病例对照研究的文献。应用Stata11.0软件合并计算A/A纯合子和携带A等位基因(T/A+A/A)杂合子与野生型T/T纯合子肺癌发生的比值比(odds ratios,OR)及95%置信区间(confidence intervals,CI),并按照亚裔与非亚裔人群进行亚组分析,评价IL-8-251T/A(rs4073)不同基因亚型与肺癌发生的相关性及与不同种族肺癌发生的相关性。结果共有6篇文献符合纳入标准。合并计算所有纳入文献中的IL-8-251T/A(rs4073)A/A纯合子和携带A等位基因(T/A+A/A)杂合子与野生型T/T纯合子肺癌发生的OR值,肺癌组3 265例OR=1.03(95% CI=0.92~1.14,异质性P=0.235),对照组3 607例OR=1.07(95% CI=0.96~1.19,异质性P=0.245),IL-8-251T/A(rs4073)基因多态性与肺癌发生无相关性。当按亚裔与非亚裔人群进行亚组分析后,发现亚裔人群中携带A等位基因(T/A+A/A)杂合子(OR=1.48,95% CI=1.04~2.11,异质性P=0.030)和A/A纯合子(OR=1.35,95% CI=1.02~1.92,异质性P=0.090)与T/T纯合子肺癌发生风险有着显著的相关性。结论 IL-8-251T/A(rs4073)基因多态性在全部人群中与肺癌发生风险无相关性,但是在亚裔人群中A等位基因的存在与肺癌发生显著相关。

关键词: 白细胞介素-8, 多态性, 肺癌, 易感性, Meta分析

Abstract:

Objective To perform a meta-analysis to evaluate the association between the interleukin-8-251T/A(rs4073) gene polymorphism and lung cancer risk. Methods A literature search at PubMed was performed to identify case-control study articles published before December 1st, 2013. The Stata11.0 software was used to calculate the pooled odds ratios(OR) with 95% confidence intervals(CI). And the analysis was stratified by Asian and non-Asian populations. Results Totally six articles met our inclusion criteria. The included studies yielded a total of 3 265 lung cancer cases and 3607 controls. For the homozygous A/A and A allele carriers(T/A + A/A), the pooled ORs for all studies combining 3 265 cases and 3 607 controls were 1.03(95% CI=0.92-1.14, P=0.235 for heterogeneity) and 1.07(95% CI=0.96-1.19, P=0.245 for heterogeneity) when compared with the homozygous wild-type genotype(T/T). When the analysis was stratified by Asian and non-Asian populations, significant risks were found among Asians for both the A allele carriers(OR=1.48, 95% CI=1.04-2.11, P=0.030 for heterogeneity) and the homozygous A/A(OR=1.35, 95% CI=1.02-1.92, P=0.090 for heterogeneity) individuals. However, no significant associations were found in non-Asian populations using any of the genetic models. Conclusion This Meta-analysis suggests that the interleukin-8-251 allele confer an increased risk for the development of lung cancer among Asians.

Key words: interleukin-8, polymorphism, lung cancer, susceptibility, Meta-analysis

中图分类号:

R734.2

真德智, 王晓彬, 李云松, 李杰, 韩毅, 刘志东. 白细胞介素-8-251T/A基因多态性和肺癌易感性的Meta分析[J]. 首都医科大学学报, 2014, 35(6): 711-716.

Zhen Dezhi, Wang Xiaobin, Li Yunsong, Li Jie, Han Yi, Liu Zhidong. Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility: a meta-analysis[J]. Journal of Capital Medical University, 2014, 35(6): 711-716.

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白细胞介素-8-251T/A基因多态性和肺癌易感性的Meta分析

Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility: a meta-analysis

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