国外肝纤维化诊断的研究热点分析

doi:10.3969/j.issn.1006-7795.2016.01.016

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (1): 83-88.doi: 10.3969/j.issn.1006-7795.2016.01.016

国外肝纤维化诊断的研究热点分析

张弘¹, 陶森², 郝彧³, 赵紫薇³, 刘妮波³, 王泓午³

1. 天津市第二人民医院慢性肝病科天津中医药大学, 天津 300092;
2. 天津中医药大学第一附属医院肝胆科, 天津 300193;
3. 天津中医药大学流行病学教研室, 天津 300193

收稿日期:2015-07-17 出版日期:2016-02-21 发布日期:2016-02-01
通讯作者: 王泓午 E-mail:tjwanghw55@163.com
基金资助:
低氧预适应转化医学北京市重点实验室开放研究课题(2015DYSY02)。

Research highlights analysis of foreign liver fibrosis diagnosis

Zhang Hong¹, Tao Sen², Hao Yu³, Zhao Ziwei³, Liu Nibo³, Wang Hongwu³

1. Department of Chronic Liver Disease, Tianjin Secondary People Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300092, China;
2. Department of Hepatobiliary, The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
3. Department of Epidemiology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Received:2015-07-17 Online:2016-02-21 Published:2016-02-01
Supported by:
This study was supported by Open Research Project of Beijing Key Laboratory for Hypoxic Preconditioning and Translational Medicine(2015DYSY02).

摘要/Abstract

摘要： 目的探讨近10年国外慢性肝病肝纤维化诊断方法的研究状况。方法对近10年已发表在PubMed、Embase、Web of science中有关慢性肝病肝纤维化诊断方法的英文文献进行检索,运用Endnote X7、Bicomb 2.0软件进行文献计量学分析。将出现频次不小于40次的有关肝纤维化诊断方法的关键词作为高频主题词,进行共词聚类分析。结果共检索出有效文献1 253篇,文献年发表量大致呈上升趋势。有关肝纤维化诊断方法的关键词5 767个,出现频率最高的高频关键词依次为肝活检、生物化学指标及超声弹性成像技术。结论肝活检病理检查仍是肝纤维化诊断的参考标准,血清生物化学指标是肝纤维化的常用检测手段。以超声为基础的肝脏弹性测定技术现已经成为肝纤维化无创诊断的主要方法。

关键词: 肝纤维化, 诊断, 文献计量学

Abstract: Objective To explore the research situation in abroad of liver fibrosis in chronic liver disease the last ten years. Methods The English literatures which were involved in liver fibrosis diagnosis from 1995 to 2014 have been retrieved on PubMed, Embase, Web of science. The bibliometric analysis has been operated with Endnote X7, Bicomb2.0 software.The high frequency keywords of liver fibrosis diagnostic test have been defined by the frequency not less than 40. At last, the high frequency keywords have been put into SPSS20.0 and made cluster analysis.Results A total of 1 253 available literatures have been screened, roughly the amount of literatures published on the rise. The 5 767 key words of liver fibrosis diagnostic test have been screened. The most frequent key words are biopsy,biological markers and elastography in the order. Conclusion Biopsy is still the diagnostic reference standard of liver fibrosis. Serological examination is common testing method. Imaging,especially ultrasonic elasticity measurement has been major noninvasive diagnostic means.

Key words: liver fibrosis, diagnosis, bibliometric analysis

中图分类号:

R575.2

张弘, 陶森, 郝彧, 赵紫薇, 刘妮波, 王泓午. 国外肝纤维化诊断的研究热点分析[J]. 首都医科大学学报, 2016, 37(1): 83-88.

Zhang Hong, Tao Sen, Hao Yu, Zhao Ziwei, Liu Nibo, Wang Hongwu. Research highlights analysis of foreign liver fibrosis diagnosis[J]. Journal of Capital Medical University, 2016, 37(1): 83-88.

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国外肝纤维化诊断的研究热点分析

Research highlights analysis of foreign liver fibrosis diagnosis

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