青光眼视神经压力损伤相关分子机制研究进展

doi:10.3969/j.issn.1006-7795.2017.01.008

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (1): 38-41.doi: 10.3969/j.issn.1006-7795.2017.01.008

青光眼视神经压力损伤相关分子机制研究进展

颜繁诚¹, 王宁利²

1. 中南大学爱尔眼科学院, 长沙 410015;
2. 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室, 北京 100730

收稿日期:2016-09-10 出版日期:2017-01-21 发布日期:2017-01-20
通讯作者: 王宁利 E-mail:wningli@vip.163.com
基金资助:
国家自然科学基金（81470635），中南大学中央高校基本科研业务费专项资金（2016zzts162）。

Progress in the molecular mechanism of optic nerve damage caused by stress in glaucoma

Yan Fancheng¹, Wang Ningli²

1. Aier School of Ophthalmology, Central South University, Changsha 410015, China;
2. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University;Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China

Received:2016-09-10 Online:2017-01-21 Published:2017-01-20
Supported by:
This study was supported by National Natural Science Foundation of China (81470635), Fundamental Research Funds for the Central Universities of Central South University(2016zzts162).

摘要/Abstract

摘要： 青光眼是一组具有特征性视神经损害及视野缺损，且以视网膜神经节细胞死亡为病理改变的疾病，是全球最常见的不可逆性致盲眼病。目前有关视神经损害的机制并不完全清楚，临床上亦缺乏有效的视神经保护治疗方法，尤其缺乏从分子水平提高视网膜神经节细胞对抗压力损害的干预方式。因此探讨视神经压力损伤的分子机制，比如经机械应力信号通路和炎性反应因素引起的视网膜继发性损伤机制等成为本领域研究热点。本文就上述研究进展进行综述。

关键词: 视网膜神经节细胞, 肿瘤坏死因子-α, 整合素

Abstract: Glaucoma is a disease characterized by optic nerve damage, visual field defect, and retinal ganglion cells (RGCs) death,which is one of the most common irreversible blinding eye disease in the world. However, the mechanism of the optic nerve damage is not clear. By now, there are no effective clinical neuroprotective treatment methods, especially it was proposed that intervention mode through the RGCs confront against the stress-related damage through molecular methods should be developed. So to explore molecular mechanisms of stress-related damage, such as mechanosensitivity signaling pathways and inflammatory factors of retinal secondary damage mechanism, are becoming hot spots in this field of research. This article summarizes the research progress in the above mentioned fields.

Key words: retinal ganglion cells, tumor necrosis factor-α, integrin

中图分类号:

颜繁诚, 王宁利. 青光眼视神经压力损伤相关分子机制研究进展[J]. 首都医科大学学报, 2017, 38(1): 38-41.

Yan Fancheng, Wang Ningli. Progress in the molecular mechanism of optic nerve damage caused by stress in glaucoma[J]. Journal of Capital Medical University, 2017, 38(1): 38-41.

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青光眼视神经压力损伤相关分子机制研究进展

Progress in the molecular mechanism of optic nerve damage caused by stress in glaucoma

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