基于皮质分析睡眠剥夺后针刺神门穴对大脑局部一致性的影响

doi:10.3969/j.issn.1006-7795.2022.03.010

首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (3): 387-392.doi: 10.3969/j.issn.1006-7795.2022.03.010

• 精神疾病中西医结合诊疗 • 上一篇下一篇

基于皮质分析睡眠剥夺后针刺神门穴对大脑局部一致性的影响

冯思同^1,2, 贾竑晓^1,2, 郑思思^1,2, 姚昊³, 冯正田^1,2, 刘鑫子^1,2, 蔡永丽^1,2, 宁艳哲^1,2*

1.首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室,北京 100088;
2.人脑保护高精尖创新中心首都医科大学,北京 100069;
3.北京中医药大学东方医院针灸科,北京 100078

收稿日期:2022-02-20 出版日期:2022-06-21 发布日期:2022-06-01
基金资助:
国家自然科学基金项目(81904120),北京市医院管理中心青年人才培养“青苗”计划(QML20201901), 北京市医院管理中心临床医学发展专项经费资助(ZYLX202129), 北京医院管理中心登峰人才(DFL20191901)。

The effect of acupuncture at Shenmen after sleep deprivation on resting-state regional homogeneity of brain: a cortical surface-based analysis

Feng Sitong^1,2, Jia Hongxiao^1,2, Zheng Sisi^1,2, Yao Hao³, Feng Zhengtian^1,2, Liu Xinzi^1,2, Cai Yongli^1,2, Ning Yanzhe^1,2*

1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China;
3. Department of Acupuncture, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China

Received:2022-02-20 Online:2022-06-21 Published:2022-06-01
Contact: *E-mail:yanzhening0923@163.com
Supported by:
National Natural Science Foundation of China(81904120),Beijing Hospitals Authority Youth Program(QML20201901),Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(ZYLX202129),Beijing Hospitals Authority's Ascent Plan(DFL20191901).

摘要/Abstract

摘要： 目的基于皮质分析方法探究针刺神门穴对24 h睡眠剥夺(sleep deprivation, SD)后大脑神经活动局部一致性(regional homogeneity, ReHo)的影响。方法对30名健康受试者进行24 h SD,随后进行针刺双侧神门穴,应用3.0T 磁共振分别在24 h SD前后以及针刺神门穴后进行静息态功能磁共振成像扫描。基于皮质分析方法采用DPABISurf软件计算每个被试24 h SD前后和针刺后脑区的ReHo值。结果与SD前相比,24 h SD后左侧第二视皮质、左侧中央前回和左侧颞横回等脑区的ReHo值显著增高;双侧后扣带回、双侧角回和双侧背外侧前额叶等脑区的ReHo值显著降低。与SD后相比,针刺神门穴后仅引起了左侧大脑半球多个脑区ReHo值的异常改变,包括后扣带回、背外侧前额叶和角回ReHo值显著降低,而颞中回ReHo值显著增高。而与SD前相比,针刺后各个脑区的ReHo值无显著性改变。结论针刺神门穴改善SD后脑功能损害的中枢效应机制可能是通过调节相应脑区的神经活动,从而降低个体觉醒、改善情绪和认知功能。

关键词: 功能磁共振, 针刺, 神门穴, 睡眠剥夺, 局部一致性

Abstract: Objective To investigate the effect of acupuncture at Shenmen after 24 h sleep deprivation (SD) on the regional homogeneity (ReHo) of brain. Methods Thirty healthy participants were included in this study. After 24 h SD, the subjects underwent the bilateral acupuncture at Shenmen. The resting state magnetic resonance imaging was acquired before and after SD, and after acupuncture. The ReHo of resting-state and post-acupuncture brain regions was calculated by using DPABISurf software based on a cortical surface-based analysis. Results Compared with that before SD, ReHo were significantly higher in brain regions such as left second visual cortex, left precentral gyrus, and left transverse temporal gyrus after 24 h SD, and ReHo were significantly lower in brain regions such as bilateral posterior cingulate gyrus, bilateral angular gyrus, and bilateral dorsolateral prefrontal gyrus. Compared with that after SD, the acupuncture at Shenmen could only remarkably modify ReHo in several brain region of left cerebral hemisphere, including significantly lower ReHo in the posterior cingulate gyrus, dorsolateral prefrontal gyrus, and angular gyrus, and significantly higher ReHo in the middle temporal gyrus. Yet compared with that before SD, there was no significant difference of ReHo in brain regions after acupuncture at Shenmen. Conclusion The mechanism of acupuncture at Shenmen on improving the impairment of brain function after SD might regulate the neural activities in the corresponding brain regions to decrease individual arousal and ameliorate mood and cognitive function.

Key words: functional magnetic resonance, acupuncture, point Shenmen, sleep deprivation, regional homogeneity

中图分类号:

R749

冯思同, 贾竑晓, 郑思思, 姚昊, 冯正田, 刘鑫子, 蔡永丽, 宁艳哲. 基于皮质分析睡眠剥夺后针刺神门穴对大脑局部一致性的影响[J]. 首都医科大学学报, 2022, 43(3): 387-392.

Feng Sitong, Jia Hongxiao, Zheng Sisi, Yao Hao, Feng Zhengtian, Liu Xinzi, Cai Yongli, Ning Yanzhe. The effect of acupuncture at Shenmen after sleep deprivation on resting-state regional homogeneity of brain: a cortical surface-based analysis[J]. Journal of Capital Medical University, 2022, 43(3): 387-392.

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基于皮质分析睡眠剥夺后针刺神门穴对大脑局部一致性的影响

The effect of acupuncture at Shenmen after sleep deprivation on resting-state regional homogeneity of brain: a cortical surface-based analysis

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