首都医科大学学报 ›› 2011, Vol. 32 ›› Issue (5): 710-713.doi: 10.3969/j.issn.1006-7795.2011.05.017

• 诺贝尔奖 • 上一篇    下一篇

揭示免疫应答的关键环节2011年诺贝尔生理学或医学奖简介

张婷, 王晓民   

  1. 首都医科大学神经生物学系,首都医科大学北京神经科学研究所,教育部神经变性病重点实验室,北京 100069
  • 收稿日期:2011-10-10 修回日期:1900-01-01 出版日期:2011-10-21 发布日期:2011-10-21
  • 通讯作者: 王晓民

The breakthrough in understanding immune response introduction of Nobel Prize in Physiology or Medicine 2011

ZHANG Ting, WANG Xiao-min   

  1. Department of Neurobiology, Beijing Institute for Neuroscience, Capital Medical University, Key Laboratory of Neurodegenerative Diseases of Ministry of Education of China, Beijing 100069, China
  • Received:2011-10-10 Revised:1900-01-01 Online:2011-10-21 Published:2011-10-21

摘要: 2011年诺贝尔生理学或医学奖颁发给分别来自法国、美国和加拿大的3位免疫学家Jules Hoffmann、Bruce Beutler和Ralph Steinman,以表彰他们对免疫应答包括先天免疫及获得性免疫中关键环节的揭示。他们的工作为疫苗改进,癌症及炎性反应的防治开辟了新的道路。

关键词: 先天免疫, 获得性免疫, 树突细胞, Toll样受体, 诺贝尔生理学或医学奖

Abstract: The Nobel Prize in Physiology or Medicine 2011 is divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity. The detailed understanding of the immune system provided by the new Nobel laureates has given other researchers the ability to improve vaccines and to attempt to stimulate immune reactions to cancer and inflammation.

Key words: innate immunity, adaptive immunity, dendritic cell, Toll-like receptor(TLR), Nobel Prize in Physiology or Medicine

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