芪参活血颗粒联合氟康唑对深部白色念珠菌感染小鼠免疫功能的影响

首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (1): 41-43.

芪参活血颗粒联合氟康唑对深部白色念珠菌感染小鼠免疫功能的影响

李世荣, 王红, 张淑文, 王宝恩

首都医科大学附属北京友谊医院感染暨急救医学科

收稿日期:2008-11-18 修回日期:1900-01-01 出版日期:2009-02-21 发布日期:2009-02-21
通讯作者: 王红

Effect of Qishenhuoxue Granule Combined with Fluconazole on the Immune Function of Mice with Systemic C. albicans Infection

Li Shirong, Wang Hong, Zhang Shuwen, Wang Baoen

Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University

Received:2008-11-18 Revised:1900-01-01 Online:2009-02-21 Published:2009-02-21

摘要/Abstract

摘要： 目的研究芪参活血颗粒联合氟康唑对深部白色念珠菌感染小鼠免疫功能的影响。方法建立小鼠深部白色念珠菌感染的动物模型,用随机数字表法分为空白对照组、模型组、中西药结合组和西药组,观察各组不同时间点实验动物血白介素-2(IL-2)水平及单核细胞表面MHC Ⅱ类分子表达水平的变化。结果芪参活血颗粒能显著增强单核细胞表面MHC Ⅱ类分子表达,提高外周血IL-2水平。结论芪参活血颗粒联合氟康唑治疗深部白色念珠菌感染的作用优于单纯使用氟康唑,芪参活血颗粒通过调节免疫力增强机体抗感染能力是其可能的作用机制之一。

关键词: 芪参活血颗粒, 主要组织相容性复合体Ⅱ类分子, 白细胞介素-2

Abstract: Objective To detect the effect of Qishenhuoxue Granule(QHG) combined with fluconazole on the immune function of mice with systemic C. albicans(CA) infection. Methods Deep CA infection mice model were established by injecting standard strain of CA via caudal vein,and were divided into 4 groups at random, treated by gastrogavage with normal saline(group B), fluconazole(FCZ)+QHG(group C), fluconazole(FCZ groupD), and a blank group(group A) with normal mice for control. The MHC Ⅱ positive rate expressed on monocyte and the content of interleukin 2(IL-2) in blood serum were tested pretherapy and on the first day, the third day, the fifty day and the seventh day after treatment. Results QHG can increase MHC Ⅱ expressed on the monocyte and the level of IL-2 in serum. Conclusion The effect of QHG combined with FCZ is better than that of FCZ only, and one of the possible leven mechanism is to strengthen anti-infection ability of mice by regulating immunologic system.

Key words: Qishenhuoxue granule, MHC Ⅱ, IL-2

中图分类号:

R2-031

李世荣;王红;张淑文;王宝恩. 芪参活血颗粒联合氟康唑对深部白色念珠菌感染小鼠免疫功能的影响[J]. 首都医科大学学报, 2009, 30(1): 41-43.

Li Shirong;Wang Hong;Zhang Shuwen;Wang Baoen. Effect of Qishenhuoxue Granule Combined with Fluconazole on the Immune Function of Mice with Systemic C. albicans Infection[J]. Journal of Capital Medical University, 2009, 30(1): 41-43.

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