首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (1): 154-159.doi: 10.3969/j.issn.1006-7795.2013.01.030

• 医学前沿 • 上一篇    下一篇

从生命科学领域解读《Science》2012年度十大突破

张婷, 王晓民   

  1. 首都医科大学基础医学院神经生物学系, 北京 100069
  • 收稿日期:2013-01-10 出版日期:2013-02-21 发布日期:2013-02-25
  • 通讯作者: 王晓民 E-mail:xmwang@ccmu.edu.cn

Breakthroughs of the 2012 year of 《Science》in life science

ZHANG Ting, WANG Xiaomin   

  1. Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2013-01-10 Online:2013-02-21 Published:2013-02-25

摘要:

2012年12月20日,美国《Science》杂志公布了2012年度十大科学突破,领域涉及物理学、工程学、生命科学及其他科学。其中,生命科学领域的重要发现包括:"古人类DNA序列的完美呈现","基因组的巡航导弹","超越基因的基因组", "X射线激光器测定蛋白质结构","脑机接口的成功应用"以及"干细胞诱导成为卵细胞"。本文主要针对这六项突破进行解读。

关键词: 古人类DNA, 转录激活子样效应因子核酸酶, DNA元件百科全书, 蛋白质结构, 脑机接口, 干细胞

Abstract:

This year saw leaps and bounds in physics, along with significant advances in engineering, life science and many other areas. In keeping with tradition, Science’s editors and staff have selected a winner and nine runners-up. In this review, the following six breakthroughs in life science will be explained, including "a home run for ancient DNA", "genomic cruise missiles", "genomics beyond genes", "first protein structure from an X-ray laser", "brain-machine interfaces start to get a grip" and "making eggs from stem cells".

Key words: ancient DNA, transcription activator-like effectors nucleases, the encyclopedia of DNA elements, protein structure, brain-machine interface, stem cell