初诊2型糖尿病病人血清维生素D浓度与甲状腺功能及临床指标的关系

doi:10.3969/j.issn.1006-7795.2017.02.005

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (2): 167-171.doi: 10.3969/j.issn.1006-7795.2017.02.005

初诊2型糖尿病病人血清维生素D浓度与甲状腺功能及临床指标的关系

崔丽梅¹, 刘翠平¹, 傅汉菁², 严晔华¹, 郑晓敏¹, 陶静¹, 冯建萍^2,3, 袁明霞^2,3, 杨金奎^2,3

1. 北京市垂杨柳医院内分泌科, 北京 100022;
2. 首都医科大学附属北京同仁医院内分泌科, 北京 100730;
3. 糖尿病防治研究北京市重点实验室, 北京 100730

收稿日期:2017-01-20 出版日期:2017-03-21 发布日期:2017-04-17
通讯作者: 崔丽梅,E-mail:clm812@163.com E-mail:clm812@163.com
基金资助:
国家自然科学基金（81370946，81400824，81300726），北京市自然科学基金（7131005）

Correlation between serum vitamin D level and thyroid function and clinical characteristics in the newly-diagnosed type 2 diabetes mellitus patients

Cui Limei¹, Liu Cuiping¹, Fu Hanjing², Yan Yehua¹, Zheng Xiaomin¹, Tao Jing¹, Feng Jianping^2,3, Yuan Mingxia^2,3, Yang Jinkui^2,3

1. Department of Endocrinology, Beijing Chuiyangliu Hospital, Beijing 100022, China;
2. Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
3. Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China

Received:2017-01-20 Online:2017-03-21 Published:2017-04-17
Supported by:
This study was supported by National Natural Science Foundation of China(81370946, 81400824, 81300726), Natural Science Foundation of Beijing (7131005)

摘要/Abstract

摘要： 目的探讨初诊2型糖尿病（type 2 diabetes mellitus，T2DM）病人血清维生素D与甲状腺功能及临床指标的关系。方法选择北京市垂杨柳医院内分泌科2015年5月至2016年10月的初诊2型糖尿病病人239例，根据血清25-羟维生素D[25-hydroxy vitamin D，25（OH）D]值分为：≥30 ng/mL为正常组、20 ng/mL≤25（OH）D<30 ng/mL为不足组、10 ng/mL≤25（OH）D<20 ng/mL为缺乏组、<10 ng/mL为严重缺乏组，比较血清25（OH）D与临床指标及甲状腺功能的关系。结果初诊2型糖尿病病人血清维生素D缺乏的患病率为56.9%，随着血清25（OH）D下降，年龄、糖化血红蛋白（glycosylate hemoglobin，HbA1c）、促甲状腺激素（thyroid stimulating hormone，TSH）逐渐增加，各组间比较差异有统计学意义（P<0.05）。线性回归分析结果显示血钙（calcium，Ca）、甲状旁腺素（parathyroid hormone，PTH）与血清25（OH）D呈独立正相关（P<0.05）;性别、年龄、吸烟、HbA1c、TSH与血清25（OH）D呈独立负相关（P<0.05）。结论女性、年龄、吸烟、HbA1c、TSH是初诊2型糖尿病病人血清25（OH）D缺乏的独立危险因素。

关键词: 2型糖尿病, 维生素D, 甲状腺功能, 促甲状腺激素

Abstract: Objective To observe relation between serum vitamin D level and thyroid function, clinical characteristics in the newly-diagnosed type 2 diabetes mellitus(T2DM) patients.Methods A total of 239 patients with the newly-diagnosed T2DM were selected in Department of Endocrinology, Beijing Chuiyangliu Hospital from May 2015 to October 2016. According to serum 25-hydroxyvitamin D[25(OH)D] level, these patients were divided into four groups:normal group ≥30 ng/mL, insufficiency group 20 ng/mL≤25(OH)D<30 ng/mL, deficiency group 10 ng/mL≤25(OH)D<20 ng/mL and severe deficiency group<10 ng/mL. Clinical characteristics and thyroid function were compared in these groups.Results The incidence of serum 25(OH)D deficiency was 56.9% in the newly-diagnosed T2DM group.There were significant differences in age, glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH) in these groups (P<0.05).The linear regression analysis showed that serum calcium (Ca), parathyroid hormone (PTH) were positively correlated with serum 25(OH)D (P<0.05), but gender, age, smoking, HbA1c, TSH were negatively correlated with serum 25(OH)D (P<0.05).Conclusion Female, age, smoke, HbA1c, TSH are important risk factors for deficiency of serum 25(OH)D in the newly-diagnosed T2DM patients.

Key words: type 2 diabetes mellitus, vitamin D, thyroid function, thyroid stimulating hormone

中图分类号:

崔丽梅, 刘翠平, 傅汉菁, 严晔华, 郑晓敏, 陶静, 冯建萍, 袁明霞, 杨金奎. 初诊2型糖尿病病人血清维生素D浓度与甲状腺功能及临床指标的关系[J]. 首都医科大学学报, 2017, 38(2): 167-171.

Cui Limei, Liu Cuiping, Fu Hanjing, Yan Yehua, Zheng Xiaomin, Tao Jing, Feng Jianping, Yuan Mingxia, Yang Jinkui. Correlation between serum vitamin D level and thyroid function and clinical characteristics in the newly-diagnosed type 2 diabetes mellitus patients[J]. Journal of Capital Medical University, 2017, 38(2): 167-171.

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初诊2型糖尿病病人血清维生素D浓度与甲状腺功能及临床指标的关系

Correlation between serum vitamin D level and thyroid function and clinical characteristics in the newly-diagnosed type 2 diabetes mellitus patients

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