Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ

doi:10.3969/j.issn.1006-7795.2012.04.025

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (4): 538-543.doi: 10.3969/j.issn.1006-7795.2012.04.025

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Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ

FU Wen-zhuo, WU Ying-ting, ZHANG Jin-lu

Medical Experiment and Test Centre, Capital Medical University, Beijing 100069, China

Received:2012-03-15 Revised:1900-01-01 Online:2012-08-21 Published:2012-08-21

Abstract

Abstract: Type Ⅱ diabetes is one of the most common chronic diseases. The drugs which have pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ have some effect in the treatment of type Ⅱ diabetes. Therefore intense interest has risen towards pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ inhibitors recently. In this review, we summarized the mechanism, characteristic structure, structure-activity relationship and progress of pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ, to provide a basis for structure-based drug design to the dipeptidyl peptidase-Ⅳ.

Key words: dipeptidyl peptidase-Ⅳ inhibitors, pyrrolidine derivatives, structure-activity relationship

CLC Number:

R587.1

FU Wen-zhuo;WU Ying-ting;ZHANG Jin-lu. Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ[J]. Journal of Capital Medical University, 2012, 33(4): 538-543.

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Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ

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