Relationship between diabetic nephropathy and hearing loss in type 2 diabetes mellitus

doi:10.3969/j.issn.1006-7795.2019.01.006

Abstract

Abstract: Objective To investigate the relationship between diabetic nephropathy (DN) and hearing loss in type 2 diabetes mellitus (T2DM) patients with different stages of renal function by testing the performance on auditory function. Methods According to the urinary albumin excretion rate (UAER), 40 patients with non-diabetic nephropathy (DM group), 28 patients with early diabetic nephropathy (DN Ⅲ group), and 27 patients with clinical diabetic nephropathy (DN Ⅳ group) were collected in this study. The glomerular filtration rate (GFR) and creatinine (Cr) were simultaneously tested, and then the auditory function were compared via examination of the pure tone audiometry and a coustic immittance. Results The hearing loss in DM, DN Ⅲ and DN Ⅳ groups mainly occurred at high frequency, with incidence of 60.0%, 71.4% and 92.6%, respectively, The difference is statistically significant. Pure tone audiometry results suggested an increased trend in the hearing threshold with the increase of the frequency of detection.The hearing threshold of DN Ⅲ and DN Ⅳ groups were higher than DM group at all frequencies (P<0.01). The hearing threshold of DN Ⅳ group was higher than that of DN Ⅲ group, and DN Ⅲ group higher than DM group at 250, 500, 1 000, 4 000 Hz (P<0.01). Correlation analysis showed that hearing threshold at high frequency was positively correlated with UAER (r=0.346, P=0.001), but negatively correlated with GFR (r=-0.230,P=0.025). Conclusion Diabetic nephropathy was closely correlated with hearing loss in patients with type 2 diabetes mellitus, the risk of hearing loss increased with an exacerbation of kidney disease. The hearing screening of patients with DN should be performed actively to detect hearing defectiveness and intervene at very early stage.

Key words: type 2 diabetes mellitus, diabetic nephropathy, hearing loss

CLC Number:

R587.1

Zhao Mingyue, Liu Bo, Wang Peng, Yang Yi. Relationship between diabetic nephropathy and hearing loss in type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2019, 40(1): 27-34.

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https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I1/27

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