Relations between infected with Helicobacter pylori and diabetic nephropathy in the patients with newly-diagnosed type 2 diabetes mellitus

doi:10.3969/j.issn.1006-7795.2020.01.005

Abstract

Abstract: Objective To study the relation between Helicobacter pylori(HP) infection and risk of diabetic nephropathy(DN) in the newly-diagnosed type 2 diabetes mellitus(T2DM) patients. Methods Totally 371 patients with the newly-diagnosed T2DM were enrolled between May 2014 and May 2018 at Department of Endocrinology, Beijing Chuiyangliu Hospital.According to urinary microalbumin to creatine ratio(UACR), these patients were divided into three groups:DN0 group (n=215), with UACR (male <2.5 mg/mmol and female<3.5 mg/mmol); DN1 group (n=128), with UACR (male 2.5 mg/mmol ≤ UACR < 30 mg/mmol, female 3.5 mg/mmol ≤ UACR < 30 mg/mmol); DN2 group(n=28), with UACR ≥ 30 mg/mmol.Results Single factor analysis showed that HP infection was associated with DN microalbuminuria (OR=1.77, 95% CI:1.103-2.851), but HP infection wasn't associated with DN clinical proteinuria.The Logistic regression analysis showed that the risk of DN was 2.52 fold higher in newly-diagnosed type 2 diabetic patients with positive HP than those with negative HP(OR=2.516, 95%CI:1.305-4.849).Conclusion HP infection is related to DN in newly-diagnosed T2DM patients. HP infection can increase the risk of DN in T2DM patients.

Key words: type 2 diabetes mellitus, diabetic nephropathy, Helicobacter pylori, risk factors

CLC Number:

R587

Li Bin, Cui Limei, Lyu Naqiang, Yan Yehua, Zheng Xiaomin, Tao Jing, Lui Cuiping. Relations between infected with Helicobacter pylori and diabetic nephropathy in the patients with newly-diagnosed type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2020, 41(1): 27-30.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.01.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I1/27

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