Abstract: Objective To describe the genotype distribution characteristics of human papillomavirus (HPV) infection in male patients with condyloma acuminatum (CA). To explore the potential risk factors of the recurrence and provide scientific reference for the prevention and treatment of CA. Methods Total of 167 male CA patients who visited dermatology and venereology department of Civil Aviation General Hospital were selected as the research subjects. HPV genotypes were detected in skin tissue of the patients by DNA chip technology. A patient questionnaire was designed and compiled to collect the sociodemographic characteristics, sexual behavior characteristics, disease characteristics and lifestyle characteristics of the patients. The risk factors for male CA recurrence were analyzed using univariate and multivariate binary Logistic regression analysis in the study. Results Among the 167 male CA patients, the top 5 infection rates of HPV were HPV6 (62.28%), HPV11(39.52%), HPV16(17.37%), HPV42(14.37%) and HPV43(11.38%), respectively. Single infection accounted for 42.51%, mixed infection accounted for 57.49%; Low risk HPV infection accounted for 97.18% of single infection. In the mixed infection, the high - low - risk mixed type accounted for 93.75%. Long course of disease (OR=6.447), high-risk HPV infection (OR=4.868), number of 5 or more lesions (OR=5.780), staying up late (OR=4.149) and smoking (OR=3.671) were independent risk factors for male CA recurrence (P＜0.05). Conclusion HPV infection in male CA patients is mainly low risk HPV 6 and 11, mixed infection is higher than single infection, and the high-low-risk mixed infection is more common. HPV type, course of disease, number of lesions and bad living habits are closely related to the recurrence of male CA, and corresponding prevention and treatment measures should be taken accordingly in clinic.

Key words: male, condyloma acuminatum, human papilloma virus, recurrence risk factors