Effects of oral contraceptives on sexual function in PCOS patients

doi:10.3969/j.issn.1006-7795.2018.04.004

Abstract

Abstract: Objective To investigate the effects of oral contraceptives on sexual function in polycystic ovary syndrome (PCOS) patients. Methods The online questionnaire was completed by PCOS patients in clinic. PCOS patients in the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University were enrolled. They were divided into two groups taking oral contraceptives (OC group) not taking OC (NOC group). The primary endpoint was the Female Sexual Function Index (FSFI) score, with additional questions on contraception, sexual activity, relationship stability, pregnancy and other factors which may influence sexual function. Results Totally 210 PCOS patients were recruited in this study to participate in the survey using the online questionnaire. Of all women participating, 126 were taking oral contraceptives (OC group) and 84 were not taking OC (NOC group). Among OC users, the median FSFI total score was 26.35, and 50.79% showed high risk of female sexual dysfunction (FSD). Regarding NOC group, the median FSFI total score was 26.85, 47.62% showed high risk of FSD. There was no significant difference between two groups (P=0.635). Also, no differences of FSFI scores were seen in patients taking 35 μg ethinyl estradiol (EE)/2 mg cyproterone acetate (CPA), 30 μg EE/3 mg drospirenone(DRSP), and 30 μg EE/150 μg desogestrel. Relationship stability and sexual activity were found to be associated with sexual function in PCOS patients. Conclusion There was no significant difference between OC users and not taking OC users in PCOS patients. Different progestins in OCs and the EE dosage in OCs have no significant influence on sexual function in PCOS patients. Regarding PCOS patients, sexual activity and relationship stability may be risk factors of FSD.

Key words: female sexual dysfunction, Female Sexual Function Index (FSFI), risk factors, polycystic ovary syndrome (PCOS), oral contraceptive

CLC Number:

R711.75

Du Juan, Ruan Xiangyan, Alfred O. Mueck. Effects of oral contraceptives on sexual function in PCOS patients[J]. Journal of Capital Medical University, 2018, 39(4): 499-504.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.04.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I4/499

References

[1] Hatzimouratidis K, Hatzichristou D. Sexual dysfunction:classifications and definitions[J]. J Sex Med, 2007, 4(1):241-250.
[2] Graziottin A, Serafini A, Palacios S. Aetiology, diagnostic algorithms and prognosis of female sexual dysfunction[J]. Maturitas, 2009, 63(2):128-134.
[3] Li R, Zhang Q, Yang D, et al. Prevalence of polycystic ovary syndrome in women in China:a large community-based study[J]. Hum Reprod, 2013, 28(9):2562-2569.
[4] Davis S R, Davison S L, Donath S. Circulating androgen levels and self-reported sexual function in women[J]. JAMA, 2005, 294(1):91-96.
[5] Rotterdam ESHRE/ASRM-sponsored. PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome[J]. Hum Repro, 2004, 19(1):41-47.
[6] Sun X, Li C, Jin L, et al. Development and validation of Chinese version of female sexual function index in a Chinese population-a pilot study[J]. J Sex Med, 2011, 8(4):1101-1111.
[7] Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI):cross-validation and development of clinical cutoff scores[J]. J Sex Marital Ther, 2005, 31(1):1-20.
[8] Pastor Z, Holla K, Chmel R. The influence of combined oral contraceptives on female sexual desire:A systematic review[J]. Eur J Contracept Reprod Health Care, 2013, 18(1):27-43.
[9] Mark K P, Leistner C E, Garcia J R. Impact of contraceptive type on sexual desire of women and of men partnered to contraceptive users[J]. J Sex Med, 2016, 13(9):1359-1368.
[10] Davis S R, Bitzer J, Giraldi A, et al. Change to either a nonandrogenic or androgenic progestin-containing oral contraceptive preparation is associated with improved sexual function in women with oral contraceptive-associated sexual dysfunction[J]. J Sex Med, 2013, 10(12):3069-3079.
[11] Smith N K, Jozkowski K N, Sanders S A. Hormonal contraception and female pain, orgasm and sexual pleasure[J]. J Sex Med, 2014, 11(2):462-470.
[12] Du J, Ruan X, Gu M, et al.Prevalence of and risk factors for sexual dysfunction in young Chinese women according to the Female Sexual Function Index:an internet-based survey[J]. Eur J Contracept Reprod Health Care, 2016, 21(3):259-263.
[13] Lara L A, Ramos F K, Kogure G S, et al. Impact of physical resistance training on the sexual function of women with polycystic ovary syndrome[J]. J Sex Med, 2015, 12(7):1584-1590.
[14] Zueff L N, Lara L A, Vieira C S, et al. Body composition characteristics predict sexual functioning in obese women with or without PCOS[J]. J Sex Marital Ther, 2015, 41(3):227-237.
[15] Kowalczyk R, Skrzypulec-Plinta V, Nowosielski K, et al. Sexuality in women with polycystic ovary syndrome[J]. Ginekol Pol, 2015, 86(2):100-106.
[16] Ferraresi S R, Lara L A, Reis R M, et al. Changes in sexual function among women with polycystic ovary syndrome:A pilot study[J]. J Sex Med, 2013, 10(2):467-473.
[17] Benetti-Pinto C L, Ferreira S R, Antunes A Jr, et al. The influence of body weight on sexual function and quality of life in women with polycystic ovary syndrome[J]. Arch Gynecol Obstet, 2015, 291(2):451-455.
[18] Wallwiener C W, Wallwiener L M, Seeger H, et al.Are hormonal components of oral contraceptives associated with impaired female sexual function? A questionnaire-based online survey of medical students in Germany, Austria, and Switzerland[J]. Arch Gynecol Obstet, 2015, 292(4):883-890.