Analysis of risk factors in patients with reflux esophagitis with extra-esophageal symptoms

doi:10.3969/j.issn.1006-7795.2022.01.022

Abstract

Abstract: Objective To determine the risk factors of the reflux esophagitis (RE) with extra-esophageal(EE)symptoms by comparing general demographic information, lifestyle, eating habits, comorbidities, current medications, anxiety, depression of RE patients with and without EE symptoms. Methods The subjects of the study were seen in the Department of Gastroenterology, Xuanwu Hospital, Capital Medical University from September 2016 to August 2017 and were clearly diagnosed as RE under gastroscopy. There were 361 cases in total. They were divided into group with EE symptoms and group without EE symptoms. The patients were surveyed on General demographic information, lifestyle, eating habits, comorbidities, current medications, Patient Health Questionnaire-9(PHQ-9) Depression Scale, General Anxiety Disorder-7(GAD-7) Anxiety Scale, Gastroesophageal Reflux Disease Questionnaire(GerdQ)and Reflux Symptom Index(RSI). Results Among the 361 patients with RE, there were 218 patients with EE symptoms. Sensation of foreign body within the throat, recurrent sore throat and chronic cough were more common, accounting for 52.75%, 46.79% and 26.15% respectively. Univariate analysis showed that there were significant differences in low education level, smoking, constipation, high body mass index (BMI), anxiety, and depression (P<0.05) between two groups. Multivariate Logistic regression analysis identified that low education level (OR:1.646, 95%CI:1.049-2.572,P<0.05), smoking (OR:2.488,95%CI: 2.047-3.281, P<0.01), high BMI (OR:1.067, 95%CI: 1.004-1.135, P<0.05), depression (OR: 1.062, 95%CI: 1.002-1.133, P<0.05), anxiety(OR: 1.061, 95%CI: 1.001-1.131, P<0.05) were the risk factors of onset of EE symptoms in RE patients. Conclusion The main extra-esophageal symptoms of RE were sensation of foreign body within the throat and recurrent sore throat, chronic cough. Low education level, high BMI, smoking, depression and anxiety were risk factors of RE with extra-esophageal symptoms.

Key words: reflux esophagitis, extra-esophageal symptoms, depression, anxiety, risk factors

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Wang Rongxin, Wang Jing, Hu Shuiqing. Analysis of risk factors in patients with reflux esophagitis with extra-esophageal
symptoms[J]. Journal of Capital Medical University, 2022, 43(1): 132-137.

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Analysis of risk factors in patients with reflux esophagitis with extra-esophageal
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