Association of OSA and asthma with the incidence rate of coronary heart disease

doi:10.3969/j.issn.1006-7795.2022.01.023

Abstract

Abstract: Objective The aim of this study was to investigate the influence of obstructive sleep apnea (OSA) with bronchial asthma (asthma) on the prevalence of coronary heart disease (CHD). Methods A total of 3 152 patients who received sleep monitoring in the Sleep Medical Center of Xuanwu Hospital, Capital Medical University from October 2002 to September 2020 were retrospectively analyzed. All patients were divided into four groups: simple snoring group (n=1 335), bronchial asthma group (n=72), OSA group (n=1676) and OSA with asthma group (n=69). The independent risk factors of coronary heart disease were analyzed by multivariate Logistic model. Results The incidence rate of CHD in asthma with OSA group was significantly higher than that in simple snoring group, simple OSA group and simple asthma group (OR=13.389, 95%CI:7.930-22.607, P<0.01; OR=11.850, 95%CI: 7.116-19.733, P<0.01; OR=3.925, 95%CI: 1.827-8.431, P<0.01). After adjusting for age, gender, BMI and abdominal circumference, there was still statistical significance (OR=7.224, 95% CI: 3.989 - 13.083, P<0.01; OR=6.783, 95%CI: 3.811-12.073, P<0.01; OR=2.920, 95%CI: 1.240-6.878, P<0.01).There was an independent correlation betweenasthma with OSA and CHD (OR=5.464, 95% CI: 2.997-9.959, P<0.01) in patients with age ≥ 55 years and abdominal circumference ≥ 90 cm(OR=4.630, 95%CI: 2.667-8.026, P<0.01). Conclusion There is a significant correlation between asthma with OSA and CHD, especially in the elderly and central obesity patients.

Key words: obstructive sleep apnea syndrome, asthma, coronary heart disease

CLC Number:

Xia Ning, Nie Xiuhong, Wang Hao, Fan Xiaojun. Association of OSA and asthma with the incidence rate of coronary heart disease[J]. Journal of Capital Medical University, 2022, 43(1): 138-142.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.01.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I1/138

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