Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome

doi:10.3969/j.issn.1006-7795.2020.04.019

Journal of Capital Medical University ›› 2020, Vol. 41 ›› Issue (4): 613-616.doi: 10.3969/j.issn.1006-7795.2020.04.019

• Clinical Research • Previous Articles Next Articles

Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome

Yan Suying, Yao Linyin, Feng Yanjun, Li Xiping, Wei Yongxiang

Department of Otolaryngology, Beijing Anzhen Hospital, Capital Medical University;Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China

Received:2019-09-03 Online:2020-08-21 Published:2020-07-22
Supported by:
This study was supported by Beijing Municipal Administration of Hospitals Ascent Plan(DFL20150602).

Abstract

Abstract: Objective To explore the clinical efficacy and safety of domperidone combined with omeprazole in the treatment of laryngopharyngeal reflux disease (LPRD)accompanied with obstructive sleep apnea syndrome (OSA). Methods Totally 81 patients with LPRD admitted to our hospital from January 2018 to May 2019 were randomly divided into observation group and control group. The control group was treated with omeprazole, while the observation group was treated with domperidone combined with omeprazole. After 6 weeks of continuous treatment, the clinical efficacy, reflux symptom index (RSI) and reflux finding score (RFS), and pepsin concentrations were compared with eath other between the two groups. Results The total clinical effective rate of the observation group and the control group were 73.3% and 44.4%, respectively. The observation group was significantly higher than the control group (χ²=6.995, P<0.05). The RFS scale scores and the salivary pepsin concentrations were all improved after treatment compared with those before treatment, while the improvement in the treatment group was more significant than that in the control group (t=7.948, 9.495, 11.629, P<0.05). Conclusion The efficacy of domperidone combined with omeprazole in the treatment of LPRD accompanied with OSA is significant. It promotes the recovery of clinical symptoms and signs, with high safety.

Key words: domperidone, omeprazole, laryngopharyngeal reflux disease, obstructive sleep apnea syndrome (OSA)

CLC Number:

R828.6

Yan Suying, Yao Linyin, Feng Yanjun, Li Xiping, Wei Yongxiang. Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome[J]. Journal of Capital Medical University, 2020, 41(4): 613-616.

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Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome

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