Abstract: Objective To explore the association between triglyceride glucose (TyG)  index and degree of coronary artery lesion in patients with newly diagnosed coronary heart disease (CHD).  Methods A total of 290 patients admitted in the department of cardiology, Beijing Chaoyang Hospital, Capital Medical University, for coronary angiography because of chest pain were included in the study. The level of fasting blood glucose (FBG), glycosylated hemoglobin  A1c（HbA1c），triglyceride (TG) and other biochemical indicators were measured, and then the TyG index was calculated by using the value of FBG and TG. All patients were divided into non-CHD group and CHD group based on the coronary angiography results. The patients of CHD group were further stratified into groups based on the number of diseased vessels: single-vessel coronary artery disease（CAD）, double-vessel CAD, and three-vessel/left main CAD according to the degree of stenosis. Multiple Logistic regression analysis was used to evaluate the association of three-vessel/left main CAD and other parameters in CHD patients.  Results The patients of CHD group exhibited higher level of FBG and HbA1c compared with the subjects of non-CHD group ［FBG: （6.12±2.41）mmol/L  vs  （5.33±1.82）mmol/L，P<0.05； HbA1c：6.79%±1.57%  vs  6.32%±1.08%, P<0.05］.  TyG index in the three-vessels/left main disease group（8.87±0.73） was higher than that in the single （8.63±0.62）and double-vessel CAD groups （8.62±0.68）（P<0.05）. Multiple Logistic regression analysis showed age, TyG index, TG, FBG, and HbA1c were independent risk factors for three-vessel/left main CAD, and the adjusted OR value (95% confidence interval) was 2.079 (1.345, 3.213) for each additional SD of TyG index.  Conclusion TyG index was elevated in patients with three-vessel/left main CAD and it was significantly related to the risk of three-vessel/left main CAD.

Key words: coronary heart disease, triglyceride glucose index, insulin resistance