Analysis of haptoglobin gene polymorphisms and serum haptoglobin levels in patients with diabetes kidney disease

doi:10.3969/j.issn.1006-7795.2023.03.003

Abstract

Abstract: Objective To investigate the relationship between haptoglobin (Hp) gene polymorphisms, serum Hp levels and diabetic kidney disease（DKD）. Methods Hp genotypes and serum Hp levels were detected by acrylamide gel electrophoresis (PAGE) and BN Ⅱ protein analyzer in 461 patients with type 2 diabetes, who were hospitalized in the Department of Endocrinology，Beijing Tongren Hospital，Capital Medical University from June 2018 to February 2019. The study subjects were divided into two groups: the control group patients with simple diabetes (212 cases) and the case group patients with complicated chronic kidney disease (249 cases). The frequency of haptoglobin genotype, allele frequency, serum haptoglobin level and other biological indicators were compared to each other between the two groups, and statistical analysis was performed using PRISM statistical software. Results The results showed that the frequency distribution of the three genotypes Hp1-1, Hp2-1 and Hp2-2 was not statistically different in the two groups (P=0.711). Serum Hp levels were significantly higher in the case group than that in the control group (P<0.05). There were significant differences in serum Hp levels among subjects of different genotypes. In both groups, the Hp1-1 subtype had the highest serum Hp concentration, while the Hp2-2 subtype had significantly lower serum Hp levels (P<0.001). Correlation analysis showed that there was a correlation between serum Hp and hemoglobin levels. Conclusion Serum Hp levels were significantly elevated in patients with diabetic chronic kidney disease, but no significant association was found between Hp genotype and DKD. However, Hp genotype may affect the content of circulating Hp.

Key words: diabetes mellitus, diabetes kidney disease, haptoglobin, genotype

CLC Number:

R587

Li Yuyang, Zhu Xiaorong, Liu Jing, Zheng Xiaomin, Yang Jinkui, Yang Fangyuan. Analysis of haptoglobin gene polymorphisms and serum haptoglobin levels in patients with diabetes kidney disease[J]. Journal of Capital Medical University, 2023, 44(3): 375-380.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.03.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I3/375

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