The effect of androgen levels on mood disorders and sexual dysfunction in peri-and postmenopausal Chinese women

doi:10.3969/j.issn.1006-7795.2023.04.002

Abstract

Abstract: Objective To study the effect of peri-and postmenopausal androgen levels on mood disorders and female sexual dysfunction (FSD). Methods From Jan. 2022 to Dec. 2022, a total of 280 women aged 40-65 years who attended the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University were recruited and divided into 76 premenopausal, 84 perimenopausal and 120 postmenopausal women. Height, weight, blood pressure, waist circumference, and hip circumference were measured. Questionnaires on menopause-related symptoms including mood disorders and sexual dysfunction were administered. The peri-and postmenopausal women were divided into emotional disorders group and control group, sexual dysfunction group and control group. The levels of serum follicle stimulating hormone(FSH), luteinizing hormone(LH), and estradiol(E2) were measured with chemiluminescence immunoassay, and the levels of serum sex hormone binding globulin(SHBG), total testosterone(TT), free testosterone(FT), bioactive testosterone(BT), dehydroepiandrosterone(DHEA), dehydroepiandrosterone sulfate(DHEA-S), androstenedione(A2), and dihydrotestosterone(DHT) were tested with liquid chromatography-tandem mass spectrometry(LC-MS/MS).Results Compared with premenopausal women, the serum levels of FT, BT, A2, DHEA, and DHEA-S were significantly lower in peri- and postmenopausal women (P < 0.05), but not significantly different between peri- and postmenopausal women (P > 0.05). The serum TT levels were slightly lower in peri- and postmenopausal women, but the difference was not significant (P > 0.05). The serum TT levels were negatively correlated with mood disorders (P<0.05) and serum DHEA-S levels were negatively correlated with sexual dysfunction (P<0.05).Conclusions Multiple androgen levels declined in peri- and postmenopausal women, mood disorders were negatively correlated with serum TT levels, and FSD was negatively correlated with serum DHEA-S levels.

Key words: perimenopause, menopause, mood disorders, female sexual dysfunction, androgens

CLC Number:

R711.75

Wang Zhikun, Ruan Xiangyan, Ju Rui, Yang Yu, Jiang Lingling, Cheng Jiaojiao, Li Yanqiu, Gu Muqing, Liu Lili, Wang Zecheng, Alfred O.Mueck. The effect of androgen levels on mood disorders and sexual dysfunction in peri-and postmenopausal Chinese women[J]. Journal of Capital Medical University, 2023, 44(4): 517-523.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.04.002

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I4/517

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