Effects of primary ovarian insufficiency on glucose and lipid metabolism and biochemical parameters in patients

doi:10.3969/j.issn.1006-7795.2017.04.004

Abstract

Abstract: Objective To compare the endocrine and metabolic parameters of primary ovarian insufficiency (POI) patients with menopausal women and normal control group, and to analyze the differences of the endocrine indicators, glucose and lipid metabolism indicators and other biochemical indicators between POI group, menopausal women and normal control group,in order to increase the attention to the health status of patients with POI. Methods A total of 108 patients diagnosed with POI, 114 menopausal women and 63 normal women. Sex hormones, glucose and lipid metabolism, and other biochemical indicators were compared. The error of the relevant detection kit and the batch error is less than 3% to 5%. Results There was no significant difference in body mass index (BMI) among the three groups (P>0.05). There were significant differences between follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E₂) (P< 0.05 ). The levels of total cholesterol (TC), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR) in the POI group were significantly higher than those of the control group (P<0.05 ), high density lipoprotein-cholesterol (HDL-C) and testosterone (T) levels were significantly lower than those of the control group (P<0.05). Conclusion In this study, TC, FINS, HOMA-IR and HDL-C of POI patients had reached menopausal women (P<0.05). The clinicians should intervene and treat POI patients as soon as possible.

Key words: primary ovarian insufficiency, menopause, metabolic of glucose and lipid, sex hormones

CLC Number:

Li Xue, Ruan Xiangyan, Wang Husheng, Li Yanglu, Zhao Yue, Gu Muqing, Du Juan, Song Jinghua, Jin Fengyu, Alfred O. Mueck. Effects of primary ovarian insufficiency on glucose and lipid metabolism and biochemical parameters in patients[J]. Journal of Capital Medical University, 2017, 38(4): 504-508.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.04.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I4/504

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