The effect of mature follicle sex hormones on pregnancy in the period of ovulation induction in patients with polycystic ovary syndrome

doi:10.3969/j.issn.1006-7795.2020.04.006

Abstract

Abstract: Objective To investigate the relationship between six sex hormones of mature follicle in ovulation induction cycle and pregnancy in patients with polycystic ovary syndrome(PCOS). Methods Totally 198 patients (470 cycles of ovulation induction) with PCOS, who were willing to receive ovulation induction treatment for pregnancy in the Beijing Obstetrics and Gynecology Hospital, Capital Medical University from March 2019 to January 2020, signed voluntarily informed consent to participate in this research project. According to whether the patients are pregnant after ovulation induction treatment, they are divided into pregnant and non-pregnant groups. The age, body mass index (BMI), waist circumference, hip circumference, basic glycolipid metabolism, liver and kidney function indexes, endometrial thickness, type, mature follicle size, and sex hormones of the two groups were compared. The sex hormones included follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), progesterone(P), prolactin (PRL)and testosterone (T). Results The E2 and T of mature follicles in the period of ovulation induction in the pregnant group were higher than those in the non-pregnant group. The years of infertility in the pregnant group was significantly shorter than that in the non-pregnant group, the days of mature follicles was more than that in the non-pregnant group, and the endometrial thickness and the size of mature follicles in the pregnant group were significantly higher than those in the non-pregnant group (P<0.05). There was no significant difference in age, BMI, waist circumference, hip circumference, glycolipid metabolism, liver and kidney function index, number of ovulation monitoring cycles, endometrial typing, FSH, LH, PRL, and P between pregnant and non-pregnant women (P>0.05). The results of multivariate analysis showed correlation between E2 (pg·mL^-1) and pregnancy with OR=1.003 (95% CI:1.001-1.006). Conclusions The elevation of E2 levels in mature follicles during ovulation induction cycle in patients with PCOS has positive effects on the likelihood of getting pregnant, which could play a guiding role in the successful pregnancy of ovulation induction treatment.

Key words: polycystic ovary syndrome, ovulation induction, six sex hormones, clinical pregnancy rate

CLC Number:

R711.59

Qin Shuang, Ruan Xiangyan, Wang Binhong, Ju Rui, Zhang Luping, Dou Zhuli, Cheng Jiaojiao, Jin Jing. The effect of mature follicle sex hormones on pregnancy in the period of ovulation induction in patients with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2020, 41(4): 530-535.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.04.006

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I4/530

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