Effects of ketogenic diet on menstruation and fertility in overweight/obese women with polycystic ovary syndrome

doi:10.3969/j.issn.1006-7795.2021.06.019

Abstract

Abstract: Objective To evaluated the effect of ketogenic diet on fertility in overweight/obese women with polycystic ovary syndrome. Methods Overweight/obese patients with polycystic ovary syndrome who visited the gynecological clinic from January 2019 to January 2020 were given ketogenic diet intervention for 12 weeks and followed up for 1 year. The differences of weight, menstrual cycle and pregnancy before and after the intervention were compared. Results A total of 52 patients were included. The median age was 29 years (23-39 years). The median time for diagnosis of polycystic ovary syndrome was 5 years (1-8 years). After ketogenic diet intervention, body weight decreased significantly (75.40±9.74 vs 65.48±8.30 kg, P＜0.001), menstrual cycle shortened significantly [(74.71±45.36) d vs (31.44±4.48) d, P＜0.001], and menstrual disorder rate decreased from 71.15% to 21.15%. There were 29 infertile patients who had fertility requirements before ketogenic diet, and 15 patients were pregnant after intervention, including 1 case of embryo suspension, and the other 14 cases were pregnant to full term. The pregnancy rate was 51.72% and the live birth rate was 48.28%. The average time of pregnancy was 2.4 months from the end of intervention (0.5-10.0 months). The average gestational age of delivery was (39.00±1.13) weeks. The mode of delivery: vaginal delivery accounted for 85.71%, cesarean section 21.43%, neonatal birth weight averaged (3.26±0.48) kg, only 2 cases had gestational diabetes during pregnancy, and 1 cases had gestational hypertension. Conclusion Ketogenic diet can reduce weight, shorten menstrual cycle, improve infertility and reduce pregnancy complications in overweight/obese women with polycystic ovary syndrome.

Key words: ketogenic diet, polycystic ovary syndrome, obesity, menstrual cycle, fertility

CLC Number:

R711

Li Jian, Bai Wenpei, Jiang Bo, Bai Liran, Wu Fengyun. Effects of ketogenic diet on menstruation and fertility in overweight/obese women with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2021, 42(6): 1021-1025.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.06.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I6/1021

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