Study on pregnancy management mode of pre-pregnancy obese or overweight women and analysis of obesity related placental factors

doi:10.3969/j.issn.1006-7795.2022.05.017

Abstract

Abstract: Objective To explore the pregnancy management mode and placental factor changes of pre-pregnancy obese or overweight women.Methods Totally 149 singleton pregnant women with pre-pregnancy body mass index (BMI)≥25 kg/m² were collected. They were divided into diet guidance group and routine examination group. Pregnant women with normal pre-pregnancy BMI in the same period were taken as control. Then, expression of CTRP6 and tumor necrosis factor-α (TNF-α) in placenta of pregnant women with different pre-pregnancy BMI were detected by immunohistochemistry. Results After dietary guidance, the weight gain during pregnancy, postpartum hemorrhage and dystocia rate of pre-pregnancy obese/overweight women were significantly reduced, but there was no significant difference in neonatal weight, and the cesarean section rate and the incidence of gestational diabetes mellitus(GDM) were still significantly higher than those in the control group. The expression of CTRP6 and TNF-α in placenta of pre-pregnancy obese/overweight women were significantly higher than those of women with pre-pregnancy normal/underweight BMI. The expression of CTRP6 in placenta of pregnant women with GDM was also significantly increased. Conclusion For pre-pregnancy obese and overweight pregnant women, effective dietary control during pregnancy can reduce the weight gain during pregnancy, but it does not reduce the neonatal weight. Therefore, pre-pregnancy weight has a greater impact on maternal and fetal complications. In pre-pregnancy obese women, CTRP6 may be involved in regulating the inflammatory response in adipose tissue, affecting blood glucose metabolism, then affecting their offspring, which should be further studied.

Key words: pregnant women, obesity, weight gain during pregnancy, neonatal weight, body mass index

CLC Number:

R714.1

Zhang Jin, Chi Jingjing, Zhang Rui, Zhang Xiaoyan, Bai Wenpei. Study on pregnancy management mode of pre-pregnancy obese or overweight women and analysis of obesity related placental factors[J]. Journal of Capital Medical University, 2022, 43(5): 774-781.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.05.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I5/774

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