Journal of Capital Medical University ›› 2020, Vol. 41 ›› Issue (4): 508-513.doi: 10.3969/j.issn.1006-7795.2020.04.002

• Menopause and Reproductive Endocrinology • Previous Articles     Next Articles

Visceral adipose tissue measured with the quantitative computed tomography:relationship between visceral adipose tissue and glycolipid metabolism in different menopausal period women

Zhang Luping1, Ruan Xiangyan1,2, Ju Rui1, Qin Shuang1, Wang Binhong1, Xu Xin1, Yang Yu1, Alfred O. Mueck1,2   

  1. 1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
    2. Department of Women's Health, University Women's Hospital and Research Center for Women's Health, University of Tubingen, Tubingen D-72076, Germany
  • Received:2020-05-08 Online:2020-08-21 Published:2020-07-22
  • Supported by:
    This study was supported by China Health Promotion Foundation (CHPF-2018-OP-11),Beijing Municipal Administration of Hospitals 'Ascent Plan' (DFL20181401), Beijing Municipal Health Commission, China International Talent Exchange Association Medical Health Technology Innovation and Talent Training Special Fund (2017041900004), Beijing Municipality Health Technology High-level Talent (2014-2-016).

PDF

16

Abstract: Objective To study the relationship between visceral adipose tissue and glycolipid metabolism in perimenopause and postmenopausal women. Methods From Sep 2018 to Feb 2020, a total of 185 women with menopausal symptoms who underwent quantitative computed tomography (QCT) testing were included in our study Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. According to the intra-abdominal fat area, the patients were divided into visceral obesity group with visceral adipose tissue (VAT) ≥ 100 cm2 and normal group. The human body index and glycolipid indexes were measured in two groups. Results In peri- and postmenopausal women, fasting blood glucose, fasting insulin, and homeostasis model assessment insulin resistance (HOMA-IR) in visceral obesity group were significantly higher than those in normal group, and VAT was positive correlation with them. In perimenopausal women, compared with the normal group, the level of triglyceride (TG) was significantly increased, and the level of high density lipoprotein-cholesterol (HDL-C) significantly decreased in visceral obesity group (P<0.05). There was no significant difference in the levels of total cholesterol, low-density lipoprotein-cholesterol (LDL-C), apolipoprotein (Apo) A and Apo B (P>0.05). The linear correlation analysis indicated that VAT was positively correlated with TG and Apo B (P<0.05). VAT was negatively correlated with HDL-C and Apo A (P<0.05). There was no significant correlation between VAT, total cholesterol (TC) and LDL-C (P>0.05). In postmenopausal women, compared with the normal group, the level of LDL-C and Apo B were significantly increased, and the level of HDL-C and Apo A were significantly decreased in visceral obesity group (P<0.05). There were no significant differences in the level of TC and TG (P>0.05). The linear correlation analysis indicated that VAT was positively correlated with Apo B. VAT was negatively correlated with HDL-C and Apo A. There was no significant correlation with TC, TG, and LDL-C (P>0.05). Conclusion Visceral adipose tissue is closely correlated with glycolipid metabolism disorder in peri- and postmenopausal women. More attention should be paid to the relationship between local adipose tissue distribution and health.

Key words: visceral adipose tissue, glycolipid metabolism, quantitative computed tomography (QCT), visceral obesity

CLC Number: