Analysis on the characteristics of the patients and effects of ovarian tissue cryopreservation in the first ovarian tissues cryopreservation bank in China

doi:10.3969/j.issn.1006-7795.2021.04.003

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (4): 521-525.doi: 10.3969/j.issn.1006-7795.2021.04.003

• Menopause, Gynecological Endocrinology and Fertility Preservation • Previous Articles Next Articles

Analysis on the characteristics of the patients and effects of ovarian tissue cryopreservation in the first ovarian tissues cryopreservation bank in China

Jin Fengyu, Ruan Xiangyan^*, Du Juan, Cheng Jiaojiao, Li Yanglu, Wang Husheng, Gu Muqing, Ju Rui, Yang Yu, Wang Yuejiao, Xu Xin

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Received:2021-05-18 Online:2021-08-21 Published:2021-07-29
Contact: * E-mail:ruanxiangyan@ccmu.edu.cn
Supported by:
Natural Science Foundation of Beijing (7202047); Capital's Funds for Health Improvement and Research (2020-2-2112); Beijing Municipal Science & Technology Commission (Z161100000516143); Capital's Funds for Health Improvement and Research (2016-2-2113); Beijing Municipal Administration of Hospitals Clinical Medicine, Development of Special Funding (XMLX201710); Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401); Beijing Municipal Administration of Hospitals Incubating Program (PZ2019031).

Abstract

Abstract: Objective To evaluate the characteristics of the patients and effects of ovarian tissue cryopreservation in the first ovarian tissues cryopreservation bank in China. Methods The data of 217 female patients in the ovarian tissue cryopreservation database of Beijing Obstetrics and Gynecology Hospital (the first ovarian tissue cryopreservation bank in China) were statistically analyzed, including the diseases type characteristics, area, age distribution, and chemoradiotherapy received or not. Four specimens with diameter of 2 mm were taken from 46 patients, two of which were randomly selected for follicular count directly and the other two specimens were cryopreservation/thawing. The difference of follicular viability counts between the two groups was compared. Results The main disease type of ovarian tissue cryopreservation in Beijing Obstetrics and Gynecology Hospital is cervical cancer, accounting for 49.31%. The age group was mainly between 31 and 35 years old, accounting for 36.4% of the total number,following by age group between 26-30 years old, accounting for 25.3%. There was no significant difference in follicular viability between fresh tissue group and cryopreservation/thawing group (P>0.05). Conclusion The main diease type of ovarian tissue cryopreservation patients in Beijing Obstetrics and Gynecology Hospital is cervical cancer. Our ovarian cryopreservation technique can effectively preserve patients' fertility.

Key words: programed cryopreservation/thawing, ovarian tissue, follicle counts, fertility protection, cervical cancer

CLC Number:

R711.75

Jin Fengyu, Ruan Xiangyan, Du Juan, Cheng Jiaojiao, Li Yanglu, Wang Husheng, Gu Muqing, Ju Rui, Yang Yu, Wang Yuejiao, Xu Xin. Analysis on the characteristics of the patients and effects of ovarian tissue cryopreservation in the first ovarian tissues cryopreservation bank in China[J]. Journal of Capital Medical University, 2021, 42(4): 521-525.

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Analysis on the characteristics of the patients and effects of ovarian tissue cryopreservation in the first ovarian tissues cryopreservation bank in China

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