The first successful case report of breast cancer patient's cryopreserved ovarian tissue transplantation in China and literature review

doi:10.3969/j.issn.1006-7795.2021.02.002

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (2): 177-182.doi: 10.3969/j.issn.1006-7795.2021.02.002

• Clinical Study on Obstetrics and Gynecology • Previous Articles Next Articles

The first successful case report of breast cancer patient's cryopreserved ovarian tissue transplantation in China and literature review

Ruan Xiangyan^{1, *}, Yang Yu¹, Lu Dan², Du Juan¹, Cheng Jiaojiao¹, Gu Muqing¹, Li Yanglu¹, Jin Fengyu¹, Duan Wei³, Dai Yinmei¹, Ju Rui¹, Xu Xin¹, Matthias Korell⁴, Alfred O. Mueck⁵

1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
3. Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
4. Johanna-Etienne Hospital in Neuss, Neuss 41462, Germany;
5. Department of Women's Health, University Women's Hospital and Research Centre for Women's Health, University of Tuebingen, Tuebingen D-72076, Germany;

Received:2020-02-22 Published:2021-04-26
Contact: ^*E-mail:ruanxiangyan@ccmu.edu.cn
Supported by:
This study was supported by Natural Science Foundation of Beijing (7202047),Beijing Capital Foundation for Medical Science Development and Research (2020-2-2112,2016-2-2113),Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (XMLX201710),Foundation of Beijing Municipal Science and Technology Commission (Z161100000516143),Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401),SAFEA: Project for Key Foreign Experts (20181100005),Beijing Municipal Health Commission,China International Talent Exchange Association Medical Health Technology Innovation and Talent Training Special Fund (2017041900004,2018042000001).

Abstract

Abstract: Objective To prevent and treat iatrogenic premature ovarian insufficiency in breast cancer patient by ovarian tissue cryopreservation and transplantation.Methods Ovarian tissue cryopreservation was performed after modified radical mastectomy in a 35-year-old breast invasive ductal carcinoma [estrogen receptor α(ERα)(-), progestone receptor(PR)(-),T_1CN₂M₀] patient. Subsequently,normative and individual radiotherapy,chemotherapy and targeted therapy were performed. During and after tumor therapy,she had got amenorrhea for more than one year and experienced obvious menopause symptoms. She had been tumor-free survival consulted and evaluated by breast cancer experts. The ovarian function test showed that follicle stimulating hormone(FSH) was 101.83 IU/L and anti-Müllerian hormone(AMH) was less than 0.06 ng/mL. The data suggested that the patient's ovarian function was completely exhausted,and the patient needed and met the physical requirement for cryopreserved ovarian tissue transplantation. Consequently, the transplantation was performed. Results Two months after transplantation,the patient's menopause symptoms disappeared,FSH decreased to 7.29 IU/L, and transvaginal ultrasound showed follicular development and ovulation in the transplanted ovary. Three months after transplantation,her menstruation recovered, indicating that the patient's ovarian function was completely recovered and the cryopreserved ovarian tissue transplantation was successful. Up to now, the patient has been transplanted for nearly 3 years and the ovarian function remains normal. Conclusion This was the first successful case report of breast cancer patient cryopreserved ovarian tissue transplantation in China. Ovarian tissue cryopreservation and transplantation is a new important technology for prevention and treatment of iatrogenic premature ovarian insufficiency and fertility protection. This manuscript also reviews the literature on this issue.

Key words: ovarian tissue cryopreservation, transplantation, breast cancer, prevention-treatment, iatrogenic premature ovarian insufficiency

CLC Number:

R711.75

Ruan Xiangyan, Yang Yu, Lu Dan, Du Juan, Cheng Jiaojiao, Gu Muqing, Li Yanglu, Jin Fengyu, Duan Wei, Dai Yinmei, Ju Rui, Xu Xin, Matthias Korell, Alfred O. Mueck. The first successful case report of breast cancer patient's cryopreserved ovarian tissue transplantation in China and literature review[J]. Journal of Capital Medical University, 2021, 42(2): 177-182.

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The first successful case report of breast cancer patient's cryopreserved ovarian tissue transplantation in China and literature review

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