Analysis of the perioperative clinical efficacy of piggyback and classical non-bypass liver transplantation

doi:10.3969/j.issn.1006-7795.2020.06.014

Abstract

Abstract: Objective The clinical data of piggyback liver transplantation and classical non-bypass liver transplantation were analyzed retrospectively to compare the efficacy of the two methods on perioperative complications and case fatality rate of liver transplantation patients. Methods Liver transplantation patients from three clinical medical centers between June 2005 and June 2013 were divided into two groups: piggyback liver transplantation group and classical non-bypass liver transplantation group. T test, rank sum test and chi square test were used to compare the differences of observation indexes between the two groups, and repeated measurement analysis of variance was used to explore the difference of creatinine concentration between the two groups during perioperative period. Binary Logistics regression were used to analyze the risk factors of postoperative case fatality rate. Results A total of 1 411 patients were recruied, including piggyback liver transplantation group (n=445) and classical non-bypass liver transplantation group (n=966). Totally 54 patients died at discharge, with a case fatality rate of 3.83%. The analysis of variance of repeated measurement showed that there was no significant difference in the change trend of creatinine concentration between the two groups during the perioperative period, but there was a significant change in creatinine concentration at different time points. The results of binary Logistics regression analysis showed that there was no significant difference inthe states of dischargebetween the two operations (OR=0.679, P=0.231), the opposite result appeared in the subgroup analysis in the center 3 (OR=0.213, P=0.004). Further analysis of the data of the center 3 by binary Logistics regression analysis showed that postoperative hemofiltration, pulmonary infection and renal failure were all risk factors of postoperative death. Conclusions The creatinine concentration after operation in both groups was significantly higher than that before operation. Postoperative hemofiltration, pulmonary infection and renal failure were independent risk factors for perioperative death of liver transplantation.

Key words: piggyback liver transplantation, classical non-bypass liver transplantation, renal function, case fatality rate

CLC Number:

R617

Zhang Juxia, Wu Anshi. Analysis of the perioperative clinical efficacy of piggyback and classical non-bypass liver transplantation[J]. Journal of Capital Medical University, 2020, 41(6): 954-959.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.06.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I6/954

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