Effect of serum uric acid control on nephropathic end point in type 2 diabetes mellitus non-intervention

doi:10.3969/j.issn.1006-7795.2014.01.015

Abstract

Abstract:

Objective To investigate the effect of serum uric acid on early function decline in type 2 diabetes mellitus. Methods Totally 512 inpatients with type 2 diabetes mellitus with urinary albumin excretion rate(UAER) under 200 μg/min were included in this study. The subjects were divided into groups base on the different levels of serum uric acid. Estimated glomerular filtration rate (eGFR) of both groups were compared, 466 Type 2 diabetes mellitus inpatients without renal function decline eGFR>70 mL/(min·1.73 m²) at the starting point participated in the 2-10 years follow up study. Terminal event was defined as eGFR <60 mL/(min·1.73 m²), and survival curves were made.Results The subjects were divided into 2 groups based on the level of serum uric acid. Low serum uric acid group had higher glomerular filtration rate with better renal function. Multivariate regression analysis showed that eGFR was negatively correlated with age, serum uric acid, disease duration, body mass index(BMI),and positively correlated with bedy mass index (HGB). In the follow up study, the subjects were divided into 2 groups based on the level of serum uric acid. The lower the serum uric acid of patients is, the lower the probability of a drop in kidney function, and survival time was longer. Conclusion In patients with type 2 diabetes mellitus, high uric acid will play a key role in the progression of diabetic nephropathy as an independent risk factor. Serum uric acid levels are a strong predictor of the development of early renal function decline in patients with type 2 diabetes mellitus.

Key words: type 2 diabetes mellitus, serum uric acid, diabetic nephropathy, early renal function decline, estimated glomerular filtration rate, survival curve

CLC Number:

R587.1

Sun Xiaomeng, Wang Yingying, Liu Chang, Feng Jianping, Xu Yuan, Yang Jinkui. Effect of serum uric acid control on nephropathic end point in type 2 diabetes mellitus non-intervention[J]. Journal of Capital Medical University, 2014, 35(1): 67-72.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.01.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I1/67

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