Study on the effect of the ovarian tissue volume on estrous cycle and body weight in rats

doi:10.3969/j.issn.1006-7795.2019.04.012

Journal of Capital Medical University ›› 2019, Vol. 40 ›› Issue (4): 554-559.doi: 10.3969/j.issn.1006-7795.2019.04.012

• Gynecological Endocrinology and Menopause • Previous Articles Next Articles

Study on the effect of the ovarian tissue volume on estrous cycle and body weight in rats

Cheng Jiaojiao¹, Ruan Xiangyan^1,2, Zhou Qi³, Li Yanglu¹, Du Juan¹, Jin Fengyu¹, Gu Muqing⁴, Alfred O. Mueck^1,2

1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Department for Women's Health, University Women's Hospital and Research Center for Women's Health, University of Tuebingen, Tuebingen D-72076, Germany;
3. Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
4. Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Received:2019-05-20 Online:2019-07-21 Published:2019-07-19
Supported by:
This study was supported by Foundation of Beijing Municipal Science and Technology Commission (Z161100000516143), Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (XMLX201710),Beijing Capital Foundation for Medical Science Development and Research (2016-2-2113), SAFEA:Project for Key Foreign Experts (20181100005), Medical Health Technology Innovation and Talent Training Special Fund (2017041900004, 2018042000001), Beijing Municipality Health Technology High-level Talent (2014-2-016).

Abstract

Abstract: Objective To investigate the effect of different ovarian tissue volume on estrous cycle and body weight in rats. Methods Totally 67 10-week-old Sprague-Dawley rats were divided into 6 groups according to removed different ovarian tissue volume after one week's acclimatization. Group A,sham operation group (n=12), Group B,the half of left ovary removed (n=12),Group C,the left whole ovary (n=12),Group D,the left whole ovary and the half of right ovary removed (n=12),Group E,the left whole ovary and the three quarters of right ovary removed (n=12),Group F,both left and right ovaries removed (n=7). The vaginal smear of the rats was monitored for 9 consecutive days at 4 weeks,8 weeks,and 12 weeks after partial ovarian resection,and the body weight of the rats was monitored on the day of surgery,4 weeks,6 weeks,8 weeks,10 weeks,and 12 weeks after surgery. The effects of the ovarian volumes on the estrous cycle and body weight of the rats were analyzed. Results There was a statistically significant difference in estrous cycle between the E group and the F group and the other 4 groups (P<0.05),and the estrous cycle days of Group E,Group F were higher than that of the other 4 groups. Rats of weight in Group F is higher than that in the other 5 groups (P<0.05). Conclusion Removed one and three quarters of ovary imposed an effect on the rat's estrous cycle, and bilateral oophorectomy imposed an effect on rat's body weight.

Key words: ovarian volume, estrous cycle, ovarian tissue cryopreservation, premature ovarian insufficiency

CLC Number:

R711.77

Cheng Jiaojiao, Ruan Xiangyan, Zhou Qi, Li Yanglu, Du Juan, Jin Fengyu, Gu Muqing, Alfred O. Mueck. Study on the effect of the ovarian tissue volume on estrous cycle and body weight in rats[J]. Journal of Capital Medical University, 2019, 40(4): 554-559.

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Study on the effect of the ovarian tissue volume on estrous cycle and body weight in rats

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