Etiology of premature ovarian insufficiency in Beijing and surrounding areas

doi:10.3969/j.issn.1006-7795.2018.04.003

Abstract

Abstract: Objective Premature ovarian insufficiency (POI) not only affects women's fertility, but also significantly increases the risk of early menopause-related chronic diseases and early death. Studying the etiology/risk factors is very important for the prevention and treatment of POI. Methods From December 2016 to May 2018, 149 patients diagnosed with POI at the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University were selected. We collected patients' informations including the age, the age of diagnosis with POI, time from hospital visit to confirming POI, menstruation, history of pelvic surgery, radiotherapy and chemotherapy history, history of mumps infection, history of thyroid dysfunction, history of immune diseases such as systemic lupus erythematosus (SLE). Body height, weight, waist circumference, hip circumference, follicle stimulating hormone (FSH), estradiol (E₂), anti-müllerian hormone (AMH), inhibin B (INHB), and karyotype analysis were measured. The 149 patients were divided into two groups according to FSH values 25-40 IU/L and FSH>40 IU/L for statistical analysis of general characteristics, endocrine parameters and etiology. Results For Age, BMI, WHI, age at diagnosis of POI, time from hospital visit to confirming POI, and INHB, there was no statistically significant difference (P>0.05). For E₂ and ANH, there was a significant difference between groups (P<0.05). The E₂ value (36.60±33.39) mg/L and AMH value (0.09±0.20) in the FSH>40 IU/L group were lower than the E₂ values (66.80±56.70) mg/L and the AMH value (0.41±0.77)ng/mL in the FSH 25-40 IU/L group. Among 149 patients with POI, 53.7% (80 cases) were idiopathic, 5.4% (8 cases) were chromosomal abnormalities, 17.4% (26 cases) were iatrogenic, and 21.5% (32 cases) had a history of infection (mumps et.), 2.0% (3 cases) were immune abnormalities;FSH 25~40 IU/L group,FSH>40 IU/L group, there was no significant difference in the etiology/risk factors between groups (P>0.05). Conclusion In addition to idiopathic factor, the more important cause of POI is iatrogenic cause, indicating that the prevention and treatment of iatrogenic POI is of utmost importance.

Key words: premature ovarian insufficiency, etiology, risk factors, iatrogenic, idiopathic, chromosomal abnormalities

CLC Number:

R711.75

Cheng Jiaojiao, Ruan Xiangyan, Li Yanglu, Du Juan, Wang Husheng, Alfred O. Mueck. Etiology of premature ovarian insufficiency in Beijing and surrounding areas[J]. Journal of Capital Medical University, 2018, 39(4): 494-498.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.04.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I4/494

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