Research progress on protective effect of mesenchymal stem cells on hypoxia after human frozen-thawed ovarian tissue transplantation

doi:10.3969/j.issn.1006-7795.2020.04.007

Abstract

Abstract: Ovarian tissue cryopreservation and transplantation has been evidenced to be effective and safe. However, the hypoxia period before angiogenesis in the early stage after transplantation is a special period for the follicle loss in the transplanted ovarian tissue. Therefore, it is of great significance to improve the survival of transplanted ovarian tissue and the recovery and prolongation of ovarian function by improving the degree of oxygenation and angiogenesis in the early stage after ovarian tissue transplantation. This article reviews the early hypoxic injury after ovarian tissue transplantation and application of mesenchymal stem cells (MSCs) in ovarian tissue transplantation.

Key words: ovarian tissue cryopreservation, ovarian tissue transplantation, mesenchymal stem cell, premature ovarian insufficiency, hypoxia, neovascularization

CLC Number:

R711.75

Cheng Jiaojiao, Ruan Xiangyan, Du Juan, Gu Muqing. Research progress on protective effect of mesenchymal stem cells on hypoxia after human frozen-thawed ovarian tissue transplantation[J]. Journal of Capital Medical University, 2020, 41(4): 536-541.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.04.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I4/536

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