The impact of testosterone levels on female sexual function in menopausal transitional and postmenopausal women

doi:10.3969/j.issn.1006-7795.2024.04.005

Abstract

Abstract: Objective To explore the impact of testosterone levels on female sexual function in menopausal transitional and postmenopausal women. Methods A total of 450 menopausal transitional and postmenopausal women who visited Beijing Obstetrics and Gynecology Hospital for the first time from January to December 2023 were recruited, including 201 menopausal transitional and 249 postmenopausal women. Demographic data and medical history were collected, female sexual function and climacteric symptoms were evaluated by using female sexual function index (FSFI) scale and modified Kupperman index (KMI). The sex hormone levels were tested for all women, including total testosterone(TT), free testosterone(FT), bioactive testosterone(BioT), 4-androstenedione(A4) and estrogen. Multiple linear regression is used to explore the impact of testosterone levels on female sexual function. Results Compared with menopausal transitional women, the FSFI scores in postmenopausal women decreased significantly (P<0.05). Multiple linear regression analysis showed that BioT level was positively correlated with arousal score (β=0.190, P<0.05) and FSFI total score (β=0.178, P<0.05), FT level was positively correlated with desire (β=0.166, P<0.05), satisfaction (β=0.176, P<0.05), and FSFI total score (β=0.126, P<0.05), while TT level was not associated with FSFI scores. The KMI score is negatively correlated with the FSFI scores (P<0.05). Conclusions Female sexual dysfunction (FSD) was associated with reduced FT and BioT levels, while not associated with TT level.

Key words: perimenopause, menopause, female sexual dysfunction, testosterone

CLC Number:

R711

Wang Zhikun, Ruan Xiangyan, Liu Lili, Yang Yu, Jiang Lingling, Wang Zecheng, Alfred O.Mueck. The impact of testosterone levels on female sexual function in menopausal transitional and postmenopausal women[J]. Journal of Capital Medical University, 2024, 45(4): 589-595.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2024.04.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2024/V45/I4/589

References

［1］ Bai R H, Liu Y N, Zhang L, et al. Projections of future life expectancy in China up to 2035: a modelling study［J］. Lancet Public Health, 2023, 8(12): e915-e922.
［2］ Ruan X Y, Cui Y M, Du J, et al. Prevalence of climacteric symptoms comparing perimenopausal and postmenopausal Chinese women［J］. J Psychosom Obstet Gynaecol, 2017, 38(3): 161-169.
［3］ Zhang L Y, Ruan X Y, Cui Y M, et al. Menopausal symptoms among Chinese peri- and postmenopausal women: a large prospective single-center cohort study［J］. Gynecol Endocrinol, 2021, 37(2): 185-189.
［4］ Bachmann G A. The hypoandrogenic woman: pathophysiologic overview［J］. Fertil Steril, 2002, 77（Suppl 4）: S72-S76.
［5］ Laumann E O, Nicolosi A, Glasser D B, et al. Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the global study of sexual attitudes and behaviors［J］. Int J Impot Res, 2005, 17(1): 39-57.
［6］ Zhang C N, Tong J L, Zhu L, et al. A Population-based epidemiologic study of female sexual dysfunction risk in mainland China: prevalence and predictors［J］. J Sex Med, 2017, 14(11): 1348-1356.
［7］金宗兰, 陈萍萍, 陈梅霞, 等. 中国女性性功能障碍现状及影响因素分析［J］. 中国公共卫生, 2021, 37(11): 1616-1620.
［8］ Fonseca H P, Scapinelli A, Aoki T, et al. Androgen deficiency in women［J］. Rev Assoc Med Bras (1992), 2010, 56(5): 579-582.
［9］ Mernone L, Fiacco S, Ehlert U. Psychobiological factors of sexual functioning in aging women— findings from the women 40+ healthy aging study［J］. Front Psychol, 2019, 10: 546.
［10］鞠蕊, 阮祥燕, 代荫梅, 等. 女性性功能障碍与性激素相关性的多中心横断面研究［J］. 中华生殖与避孕杂志, 2024, 44(3): 278-284.
［11］王志坤, 阮祥燕, 鞠蕊, 等. 围绝经期与绝经后女性雄激素浓度对情绪障碍及性功能障碍的影响［J］. 首都医科大学学报, 2023, 44(4): 517-523.
［12］ Kathryn I M, James A S. Androgen therapy for women after menopause ［J］. Best Pract Res Clin Endocrinol Metab, 2021, 35(6): 101592.
［13］ Whitton K, Baber R. Androgen-based therapies in women ［J］. Best Pract Res Clin Endocrinol Metab, 2024, 38(1): 101783.
［14］中国整形美容协会科技创新与器官整复分会. 女性性功能障碍诊治中国专家共识（2023年版）［J］. 中华妇产科杂志, 2023, 58(9): 641-649.
［15］ Harlow S D, Gass M, Hall J E, et al. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging［J］. Climacteric, 2012, 15(2): 105-114.
［16］中华医学会妇产科学分会绝经学组. 中国绝经管理与绝经激素治疗指南2023版［J］. 中华妇产科杂志, 2023, 58(1): 4-21.
［17］鞠蕊, 阮祥燕, 许新, 等. 围绝经期及绝经后女性性功能障碍状况及与更年期症状的关系分析［J］. 首都医科大学学报, 2020, 41(4): 503-507.
［18］ Cruz E F, Nina V J D S, Figuerêdo E D. Climacteric symptoms and sexual dysfunction: association between the Blatt-Kupperman index and the female sexual function index［J］. Rev Bras Ginecol Obstet, 2017, 39(2): 66-71.
［19］王浅浅, 阮祥燕, 田玄玄, 等. 298例围绝经期女性性功能障碍患病率及患病类型调查［J］. 首都医科大学学报, 2014, 35(4): 397-401.
［20］鞠蕊, 阮祥燕, 代荫梅, 等. 不同生殖衰老分期及激素替代治疗的绝经期女性性功能障碍状况分析［J］. 首都医科大学学报, 2021, 42(4): 533-539.
［21］ Battle D E. Diagnostic and statistical manual of mental disorders(DSM)［J］. Codas, 2013, 25(2): 191-192.
［22］多囊卵巢综合征雄激素质谱检测共识专家组, 中国人体健康科技促进会生育力保护与保存专业委员会. 多囊卵巢综合征雄激素质谱检测专家共识［J］. 检验医学, 2023, 38(3): 203-208.
［23］ Jayasena C N, Alkaabi F M, Liebers C S, et al. A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women［J］. Clin Endocrinol (Oxf), 2019, 90(3): 391-414.
［24］ Ju R, Ruan X Y, Yang Y, et al. A multicentre cross-sectional clinical study on female sexual dysfunction in postmenopausal Chinese women［J］. Maturitas, 2023, 172: 15-22.

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