Effects of alpha-syn of N-methy-D-asparatic acid receptor in hippocampus neurons

doi:10.3969/j.issn.1006-7795.2014.05.016

Journal of Capital Medical University ›› 2014, Vol. 35 ›› Issue (5): 601-603.doi: 10.3969/j.issn.1006-7795.2014.05.016

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Effects of alpha-syn of N-methy-D-asparatic acid receptor in hippocampus neurons

Chen Yudong^1,2, Yang Weiwei^1,2, Li Xin^1,2, Yu Shun^1,2

1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China;
2. Beijing Gariatric Medical and Clinical Center, Beijing 100053, China

Received:2014-07-21 Online:2014-10-21 Published:2014-10-20
Supported by:
This study was supported by National Natural Science Foundation of China(81000162).

Abstract

Abstract:

Objective To elucidate the mechanisms of α-Syn inhibiting N-methy-D-asparatic acid(NMDA)receptors activities in hippocampal neurons.Methods Whole-cell patch-clamp recording was used to assess the effects of α-Syn on the NMDA currents in normally cultured hippocampal neurons. Results Peak amplitude of NMDA-evoked currents in cultured hippocampal neurons decreased significantly compared with that of NMDA currents in normally cultured hippocampal neurons. Conclusion These results suggest that α-Syn reduce the number of hippocampal neuron membrane NMDARs, and inhibit the activity of NMDARs.

Key words: α-synuclein (α-Syn), NMDA receptors, whole-cell patch clamp

CLC Number:

R189

Chen Yudong, Yang Weiwei, Li Xin, Yu Shun. Effects of alpha-syn of N-methy-D-asparatic acid receptor in hippocampus neurons[J]. Journal of Capital Medical University, 2014, 35(5): 601-603.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.05.016

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I5/601

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Effects of alpha-syn of N-methy-D-asparatic acid receptor in hippocampus neurons

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