Abstract:

Objective To investigate the effects of Winged Euonymus Twig in the level of serum leptin and weights of high fat rats. Methods Totally 38 male wistar rats were randomly divided into blank control group(fed with ordinary diet), high fat diet group and 3 treatment groups(high dose, middle dose and low dose). High fat diet rats were treated with different dosage Winged Euonymus Twig for 4 weeks, observed the changes of body weight and serum leptin. Results The body weight and levels of serum leptin of high fat diet rats were all higher than those in the normal rats,after treated with Winged Euonymus Twig, the body weight of high dose and middle dose group were obviously decreased(P <0.01,P <0.05) and the levels of serum leptin were markedly higher(P <0.05). Conclusion Winged Euonymus Twig can increase the levels of serum leptin and decrease the body weight, this conclusion may prove that Winged Euonymus Twig can adjust glucolipid metabolism, thus provided experimental foundation for the clinical application of the plant to the patient with diabetes and hyperlipemia.

Key words: Winged Euonymus twig, serum leptin, high fat diet rats