Prospective study of BK virus infection in renal transplant recipients in a single-center

doi:10.3969/j.issn.1006-7795.2015.03.024

Abstract

Abstract:

Objective To explore the incidence and clinical course of BK virus by monitoring of BKV loads in renal transplantation. Methods There are 80 cases of renal transplant recipients were undertaken BK virus detection including urine and serum BKV DNA. To demonstrate the BK virus replication. BKVAN was diagnosed by light microscopic examination and a positive immunohistochemistry staining of anti-SV40 large T antibody in a biopsy specimen. Patients diagnosed with BKVAN were followed up and medical case histories were reviewed. Results Among the 80 patients, BKV viruria, BKV viremia and BKVAN occurred in 37.5%, 8.75% and 2.5% of kidney transplant recipients, respectively. The BKV DNA level in urine and serum remained constant and the peak time of BKV infection was at the sixth month to twelfth month post renal transplantation. Conclusion BKVAN in renal transplant recipients is an important cause of renal transplant dysfunction. Routine BK virus surveillance is effective; It tends to detect BK virus replication early, allowing reduction of immunosuppression, which results in good outcomes with renal preservation.

Key words: kidney transplantation, BK virus, BK virus associated nephropathy, allograft dysfunction

CLC Number:

R617

Yang Xiaoyong, Ren Liang, Wang Wei, Liu Hang, Hu Xiaopeng, Zhang Xiaodong. Prospective study of BK virus infection in renal transplant recipients in a single-center[J]. Journal of Capital Medical University, 2015, 36(3): 459-464.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.03.024

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I3/459

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