Comparative study of shear wave velocity and diffusion MRI for hepatic fibrosis in patients with chronic hepatitis B.

doi:10.3969/j.issn.1006-7795.2016.04.010

Abstract

Abstract: Objective To compare the value of shear wave velocity (SWV) and intravoxel incoherent motion diffusion MRI (IVIM) in evaluating the stage of hepatic fibrosis in patients with chronic Hepatitis B. Methods Totally 223 patients with HBV infection who underwent liver biopsy were selected into this research, they were divided into four groups:mild hepatic fibrosis (F1), obvious hepatic fibrosis (F2), serious hepatic fibrosis (F3), cirrhosis (F4). Eighty normal subjects were chosen as control group. The SWV of all hepatic segments s5, s6, s7, s8 and their average value were measured; 39 patients of different degrees hepatic fibrosis and 19 normal subjects accepted IVIM, the diffusion parameters (D, f, D^*) were measured. Results Among these 5 groups, the SWV of all hepatic segments had significant difference (P<0.05) except for the segment s5 between control and F1 group (P>0.05), with the development of hepatic fibrosis, SWV increase gradually. The cut-off value of ≥ F1, ≥ F2, ≥ F3 and F4 was separately 1.22 m/s, 1.30 m/s, 1.45 m/s and 1.60m/s, SWV had fine sensitivity of 92.82% and 90.12% for liver fibrosis F1 and F2, as it comes to F3 and F4, SWV get fantastic specificity of 92.27% and 95.93%. The diagnostic accuracy of SWV expressed as area under receiver operating characteristic curve (AUROC) was 0.887, 0.920, 0.952 and 0.954 for the diagnosis of hepatic fibrosis ≥ F1, ≥ F2, ≥ F3 and F4. The mean D, f and D^* values of IVIM measured in patients with hepatic fibrosis were obviously smaller than healthy subjects. As the fibrosis severity progressed, f and D^* values decreased, a trend towards lower f and D^* with the increase of fibrosis stages was statistically significant (P<0.05). f and D^* values had the ability to distinguish different fibrosis stages of F2 between F1, the best cut-off points were 0.135, 9.928×10^-3 mm²/s, respectively. Conclusion SWV could accurately evaluate the stage of obvious hepatic fibrosis in patients suffering from chronic hepatitis B; IVIM could distinguish mild liver fibrosis from obvious hepatic fibrosis, the combination of them were suitable for clinical use.

Key words: shear wave velocity, intravoxel incoherent motion diffusion MRI, hepatic fibrosis, noninvasive diagnosis

CLC Number:

Dong Changfeng, Zeng Zheng, Liu Yingxia, Li Hanying, Chen Xin, Luo Yongfang, Shan Lingbo, Huang Hua, Lu Puxuan. Comparative study of shear wave velocity and diffusion MRI for hepatic fibrosis in patients with chronic hepatitis B.[J]. Journal of Capital Medical University, 2016, 37(4): 465-471.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.04.010

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I4/465

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