Research progress on photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)

doi:10.3969/j.issn.1006-7795.2018.03.029

Abstract

Abstract: Peritoneal metastasis (PM) has long been regarded as the terminal stage or cancer spreading. Since the 1990s, an integrated treatment strategy combining cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been gradually developed by the surgical oncology community, and has definitely improved the survival in selected patients with PM. In such comprehensive treatment strategy, completeness of cytoreduction (CCR) is the most important independent prognostic factor for survival benefit. The current CRS technique, however, is inadequate to identify the minute tumor nodules hidden at less accessible sites in the abdomen and pelvis. Thus PM still accounts for the most frequent form of cancer recurrence after CRS+HIPEC. There is an urgent need to develop sharper techniques to identify the minute PM nodules. Among the emerging technologies, photodynamic diagnosis (PDD) attracts the increasing attention for PM diagnosis. This review summarizes the application of 5-aminolevulinic acid (5-ALA) -based PDD for the diagnosis and treatment of PM.

Key words: 5-aminolevulinic acid, photodynamic diagnosis, peritoneal surface malignancy, PEPT1, ABCG2, ferrochelatase

CLC Number:

R735.5

Ji Zhonghe, Liu Yang, Yutaka Yonemura, Li Yan. Research progress on photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)[J]. Journal of Capital Medical University, 2018, 39(3): 469-475.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.03.029

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I3/469

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